The impact of autophagy on peripheral synapses in health and disease
| Autor: | Franziska Wild, Muzamil Majid Khan, Rüdiger Rudolf, Said Hashemolhosseini |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Disease Mitochondrion Protein Aggregation Pathological 03 medical and health sciences 0302 clinical medicine Charcot-Marie-Tooth Disease medicine Autophagy Animals Humans Peripheral Nerves Amyotrophic lateral sclerosis business.industry Peripheral Nervous System Diseases medicine.disease Peripheral 030104 developmental biology medicine.anatomical_structure Pharmacological interventions Peripheral nervous system Synapses business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in bioscience (Landmark edition). 21(7) |
| ISSN: | 2768-6698 |
| Popis: | Alterations of autophagy have been linked to several peripheral nervous system diseases, such as amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease. Modulation of autophagy by metabolic or pharmacological interventions has been increasingly recognized as a strategy to fight many of these disorders. Cellular processes that are aberrant in case of impaired autophagy and that might lead to these diseases belong to three different categories: (1) clearing of protein aggregates, (2) regulation of vesicle and cargo turnover, and (3) disposal of damaged mitochondria. This review summarizes the present literature that addresses both, the impact and mechanisms of autophagy on the health of the peripheral nervous system and treatment proposals for human disorders associated with impaired autophagy. |
| Databáze: | OpenAIRE |
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