Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model

Autor: Yasaman Damestani, Diego E. Galan-Hoffman, Guillermo Aguilar, Pedro Cabrales, Daniel Ortiz
Rok vydání: 2015
Předmět:
Technology
medicine.medical_specialty
Materials science
Surface Properties
0206 medical engineering
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Bioengineering
Vascular permeability
02 engineering and technology
Transillumination
Electron
Yttria-stabilized-zirconia
Materials Testing
medicine
Peek
Cell Adhesion
Humans
Scanning
General Materials Science
Yttrium
Cranial implant
Dorsal window chamber model
Nanoscience & Nanotechnology
Yttria-stabilized zirconia
Titanium
Microscopy
Skull
Blood flow
Adhesion
Prostheses and Implants
Biological Sciences
021001 nanoscience & nanotechnology
Windows to the brain
020601 biomedical engineering
Nanocrystalline material
Surgery
Chemical Sciences
Microscopy
Electron
Scanning
Molecular Medicine
Nanoparticles
Implant
Zirconium
0210 nano-technology
Biomedical engineering
Zdroj: Nanomedicine : nanotechnology, biology, and medicine, vol 12, iss 7
ISSN: 1549-9642
Popis: The long-range goal of the windows to the brain (WttB) is to improve patient care by providing a technique for delivery and/or collection of light into/from the brain, on demand, over large areas, and on a chronically-recurring basis without the need for repeated craniotomies. To evaluate the potential of nanocrystalline yttria-stabilized-zirconia (nc-YSZ) cranial implant for optical therapy and imaging, in vivo biocompatibility was studied using the dorsal window chamber model in comparison with control (no implant) and commercially available cranial implant materials (PEEK and PEKK). The host tissue response to implant was characterized by using transillumination and fluorescent microscopy to measure leukocyte adhesion, blood vessel diameter, blood flow rate, and vascular permeability over two weeks. The results indicated the lack of inflammatory reaction of the host tissue to nc-YSZ at the microscopic level, suggesting that nc-YSZ is a good alternative material for cranial implants.
Databáze: OpenAIRE
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