Specific effect of thyroid hormone on testicular enzymes involved in carbohydrate metabolism II. Hyperthyroidism
| Autor: | M. Michael Aruldhas, H. Mohammed Valivullah, P. Govindarajulu |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Phosphofructokinase-1 Pyruvate Kinase Biophysics Glucosephosphate Dehydrogenase Pentose phosphate pathway Biology Hyperthyroidism Biochemistry chemistry.chemical_compound Follicle-stimulating hormone Hexokinase Internal medicine Testis medicine Animals Testosterone Glycolysis Sexual Maturation Phosphogluconate dehydrogenase Molecular Biology Phosphogluconate Dehydrogenase Thyroid Rats Inbred Strains Luteinizing Hormone Rats Thyroxine Endocrinology medicine.anatomical_structure chemistry Follicle Stimulating Hormone Pyruvate kinase Hormone |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 715:121-125 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/0304-4165(82)90057-5 |
| Popis: | The influence of thyroxine on some of the key enzymes involved in glycolytic and pentose phosphate pathways in the testes of pre-pubertal; pubertal and adult rats was studied. Thyroxine-induced (25 micrograms/100 g body weight) hyperthyroidism for 1 month resulted in no change in either hexokinase (EC 2.7.1.1) or 6-phosphofructokinase (EC 2.7.1.11) activity in the testes of rats in any age group studied. However, pyruvate kinase (EC 2.7.1.40) activity was reduced significantly in the pre-pubertal and pubertal rats. Both glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (EC 1.1.1.44) activities were markedly increased after thyroxine treatment. Withdrawal of hormone treatment resulted in reversion of enzyme activities towards normal. The results suggest that thyroxine has an age-dependent, specific effect over testicular pyruvate kinase activity. Thyroid hormone may have a direct control over the pentose phosphate pathway in the testis. |
| Databáze: | OpenAIRE |
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