Within-Day, Between-Day, and Between-Week Variability of Urinary Concentrations of Phenol Biomarkers in Pregnant Women
| Autor: | Valérie Siroux, Sarah Lyon-Caen, Enrique F. Schisterman, Céline Vernet, Antonia M. Calafat, Claire Philippat, Xiaoyun Ye, Rémy Slama |
|---|---|
| Přispěvatelé: | Siroux, Valérie, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centers for Disease Control and Prevention [Atlanta, GA, USA] (CDCP), Université Grenoble Alpes (UGA), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
[SDE] Environmental Sciences Time Factors Health Toxicology and Mutagenesis Urinary system Physiology 010501 environmental sciences MESH: Triclosan 01 natural sciences Toxicology studies 03 medical and health sciences 0302 clinical medicine MESH: Phenols MESH: Pregnancy Phenols Pregnancy MESH: Phenol Medicine Humans 030212 general & internal medicine Sulfones Adverse effect 0105 earth and related environmental sciences MESH: Humans Phenol business.industry Research MESH: Time Factors Public Health Environmental and Occupational Health MESH: Chlorophenols MESH: Adult MESH: Sulfones Triclosan [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDE]Environmental Sciences MESH: Biomarkers Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female Biomarkers Chlorophenols |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, 2018, 126 (3), pp.037005. ⟨10.1289/EHP1994⟩ Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2018, 126 (3), pp.037005. ⟨10.1289/EHP1994⟩ |
| ISSN: | 0091-6765 1552-9924 |
| Popis: | International audience; Background: Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized.Objectives: We aimed to characterize within-day, between-day, and between-week variability of phenol urinary biomarker concentrations during pregnancy.Methods: In eight French pregnant women, we collected all urine voids over a 1-wk period (average, 60 samples per week per woman) at three occasions (15±2, 24±2, and 32±1 gestational weeks) in 2012-2013. Aliquots of each day and of the whole week were pooled within-subject. We assayed concentrations of 10 phenols in these pools, and, for two women, in all spot (unpooled) samples collected during a 1-wk period. We characterized variability using intraclass correlation coefficients (ICCs) with spot samples (within-day variability), daily pools (between-day variability), and weekly pools (between-week variability).Results: For most biomarkers, the within-day variability was high (ICCs between 0.03 and 0.50). The between-day variability, based on samples pooled within each day, was much lower, with ICCs >0.60 except for bisphenol S (0.14, 95% confidence interval [CI]: 0.00, 0.39). The between-week variability differed between compounds, with triclosan and bisphenol S having the lowest ICCs (0.9).Conclusion: During pregnancy, phenol biomarkers showed a strong within-day variability, while the variability between days of a given week was more limited. One biospecimen is not enough to efficiently characterize exposure; collecting biospecimens during a single week may be enough to represent well the whole pregnancy exposure for some but not all phenols. https://doi-org.proxy.insermbiblio.inist.fr/10.1289/EHP1994. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|