Immune deficiency could be an early risk factor for altered insulin sensitivity in antiretroviral-naive HIV-1-infected patients: the ANRS COPANA cohort
| Autor: | Faroudy, Boufassa, Cécile, Goujard, Jean-Paul, Viard, Robert, Carlier, Bénédicte, Lefebvre, Patrick, Yeni, Olivier, Bouchaud, Jacqueline, Capeau, Laurence, Meyer, Corinne, Vigouroux, Isabelle, Suaud |
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| Přispěvatelé: | Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne et maladies infectieuses, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre de Diagnost ic et de Thérapeutique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu, Service de Radiologie et imagerie médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Services des Maladies Infectieuses et Tropicales [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service des maladies infectieuses et tropicales, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biochimie et hormonologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), This work was supported by grants from Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS)., ANRS COPANA Cohort Study Group, Vigouroux, Corinne, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Tenon [AP-HP] |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male MESH: CD4 Lymphocyte Count medicine.medical_treatment HIV Infections Body Mass Index Cohort Studies 0302 clinical medicine Risk Factors MESH: Risk Factors Body Fat Distribution Insulin Pharmacology (medical) 030212 general & internal medicine MESH: Cohort Studies 2. Zero hunger [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism 0303 health sciences Glucose tolerance test MESH: Cytokines biology medicine.diagnostic_test MESH: European Continental Ancestry Group MESH: HIV Infections [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism MESH: Lipoproteins 3. Good health MESH: Insulin Resistance Infectious Diseases C-Reactive Protein MESH: RNA Viral Cohort Cytokines RNA Viral Female France medicine.symptom Adult Lipoproteins MESH: Glucose Tolerance Test Inflammation MESH: Insulin White People Article MESH: Body Mass Index 03 medical and health sciences Insulin resistance Immune system MESH: Adipokines Adipokines MESH: C-Reactive Protein medicine Humans MESH: Body Fat Distribution MESH: Africa South of the Sahara Risk factor Africa South of the Sahara 030304 developmental biology Pharmacology MESH: Humans C-reactive protein MESH: Adult Glucose Tolerance Test medicine.disease MESH: Male CD4 Lymphocyte Count MESH: France Immunology biology.protein MESH: Blood Glucose Insulin Resistance MESH: Female |
| Zdroj: | Antiviral Therapy Antiviral Therapy, International Medical Press, 2012, 17 (1), pp.91-100. ⟨10.3851/IMP1916⟩ Antiviral Therapy, 2012, 17 (1), pp.91-100. ⟨10.3851/IMP1916⟩ |
| ISSN: | 1359-6535 |
| Popis: | Background The relationships between immunovirological status, inflammatory markers, insulin resistance and fat distribution have not been studied in recently diagnosed (Methods We studied 214 antiretroviral-naive patients at enrolment in the metabolic substudy of the ANRS COPANA cohort. We measured clinical, immunovirological and inflammatory parameters, glucose/insulin during oral glucose tolerance test (OGTT), adipokines, subcutaneous and visceral fat surfaces (subcutaneous adipose tissue [SAT] and visceral adipose tissue [VAT], assessed by computed tomography) and the body fat distribution based on dual-energy X-ray absorptiometry (DEXA). Results Median age was 36 years; 28% of the patients were female and 35% of sub-Saharan origin; 20% had low CD4+ T-cell counts (≤200/mm3). Patients with low CD4+ T-cell counts were older and more frequently of sub-Saharan Africa origin, had lower body mass index (BMI) but no different SAT/VAT ratio and fat distribution than other patients. They also had lower total, low-density lipoprotein and high-density lipoprotein cholesterolaemia, higher triglyceridaemia and post-OGTT glycaemia, higher markers of insulin resistance (insulin during OGTT and homeostasis model assessment of insulin resistance) and of inflammation (high-sensitivity C-reactive protein, IL-6, tumour necrosis factor (TNF)-α, sTNFR1 and sTNFR2). After adjustment for age, sex, geographic origin, BMI and waist circumference, increased insulin resistance was not related to any inflammatory marker. In multivariate analysis, low CD4+ T-cell count was an independent risk factor for altered insulin sensitivity (β-coefficient for HOMA-IR: +0.90; P=0.001; CD4+ T-cell count >500/mm3 as the reference), in addition to older age (P: +0.26 for a 10-year increase; P=0.01) and higher BMI (P: +0.07 for a 1-kg/m2 increase; P=0.003). Conclusions In ART-naive patients, severe immune deficiency but not inflammation could be an early risk factor for altered insulin sensitivity. |
| Databáze: | OpenAIRE |
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