No structural brain alterations in new daily persistent headache – a cross sectional VBM/SBM study
Autor: | Dagny Holle, Stefan Zuelow, Hans-Christoph-Diener, Christoph Kleinschnitz, Christopher Michael Weise, Mark Obermann, K. Solbach, Anders Hougard, Julia Zeller, Steffen Naegel |
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Rok vydání: | 2021 |
Předmět: |
Pediatrics
medicine.medical_specialty Medizinische Fakultät » Universitätsklinikum Essen » Zentrum für Kinder- und Jugendmedizin » Klinik für Pädiatrische Hämatologie Onkologie und Endokrinologie Headache Disorders Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie Forschungszentren » Zentrum für Medizinische Biotechnologie (ZMB) Medizin Grey matter New daily persistent headache medicine Humans voxel-based morphometry In patient ddc:610 Gray Matter business.industry brain structural correlate Headache Brain General Medicine Voxel-based morphometry Magnetic Resonance Imaging Cross-Sectional Studies medicine.anatomical_structure Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie Neurology (clinical) business |
Zdroj: | Cephalalgia. 42:335-344 |
ISSN: | 1468-2982 0333-1024 |
Popis: | Objective To identify grey matter alterations in patients suffering new daily persistent headache to enrich the pathophysiological concept of this rare headache disorder characterised by a distinct, clearly remembered onset and its instant chronification. Method Magnetic resonance-based voxel-based and surface-based morphometry was used to investigate 23 patients suffering from new daily persistent headache and 23 age- and gender-matched healthy controls with 1.5 Tesla MRI. Independent statistical analysis was performed at three sites using statistical parametric mapping, as well as FSL(FMRIB Software Library)-based approaches. Results No grey matter changes were detected using this sophisticated and cross-checked method. Conclusion The absence of structural brain changes in patients with new daily persistent headache contribute to the recent discussion regarding structural alterations in primary headache disorders in general and does not provide evidence for grey matter changes being associated with the pathophysiology of new daily persistent headache. Future research will have to determine the underlying pathophysiological mechanisms of this disorder. |
Databáze: | OpenAIRE |
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