No structural brain alterations in new daily persistent headache – a cross sectional VBM/SBM study

Autor: Dagny Holle, Stefan Zuelow, Hans-Christoph-Diener, Christoph Kleinschnitz, Christopher Michael Weise, Mark Obermann, K. Solbach, Anders Hougard, Julia Zeller, Steffen Naegel
Rok vydání: 2021
Předmět:
Pediatrics
medicine.medical_specialty
Medizinische Fakultät » Universitätsklinikum Essen » Zentrum für Kinder- und Jugendmedizin » Klinik für Pädiatrische Hämatologie
Onkologie und Endokrinologie
Headache Disorders
Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie
Forschungszentren » Zentrum für Medizinische Biotechnologie (ZMB)
Medizin
Grey matter
New daily persistent headache
medicine
Humans
voxel-based morphometry
In patient
ddc:610
Gray Matter
business.industry
brain structural correlate
Headache
Brain
General Medicine
Voxel-based morphometry
Magnetic Resonance Imaging
Cross-Sectional Studies
medicine.anatomical_structure
Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie
Neurology (clinical)
business
Zdroj: Cephalalgia. 42:335-344
ISSN: 1468-2982
0333-1024
Popis: Objective To identify grey matter alterations in patients suffering new daily persistent headache to enrich the pathophysiological concept of this rare headache disorder characterised by a distinct, clearly remembered onset and its instant chronification. Method Magnetic resonance-based voxel-based and surface-based morphometry was used to investigate 23 patients suffering from new daily persistent headache and 23 age- and gender-matched healthy controls with 1.5 Tesla MRI. Independent statistical analysis was performed at three sites using statistical parametric mapping, as well as FSL(FMRIB Software Library)-based approaches. Results No grey matter changes were detected using this sophisticated and cross-checked method. Conclusion The absence of structural brain changes in patients with new daily persistent headache contribute to the recent discussion regarding structural alterations in primary headache disorders in general and does not provide evidence for grey matter changes being associated with the pathophysiology of new daily persistent headache. Future research will have to determine the underlying pathophysiological mechanisms of this disorder.
Databáze: OpenAIRE
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