High-resolution 2-dimensional protein mapping of ?diploid? and ?aneuploid? mammary adenocarcinomas
| Autor: | G. Auer, C. Steinbeck, B. Havsteen, E. Postel, H. Busse, R. Steinbeck |
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| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty Histology High resolution Breast Neoplasms Tumor cells Adenocarcinoma Biology Epithelium Protein mapping medicine Humans Breast Isoelectric Point Molecular Biology Silver Staining Method DNA Neoplasm Cell Biology General Medicine Aneuploidy medicine.disease Tumor tissue Molecular biology Neoplasm Proteins Molecular Weight Medical Laboratory Technology Mammary Epithelium Electrophoresis Polyacrylamide Gel Female Anatomy Ploidy General Agricultural and Biological Sciences |
| Zdroj: | Histochemistry. 84:338-341 |
| ISSN: | 1432-119X 0301-5564 |
| DOI: | 10.1007/bf00482960 |
| Popis: | Two-dimensional-electrophoretic analysis has been applied to non-neoplastic mammary epithelium from eight healthy women, tumor tissue from eight "diploid" mammary adenocarcinomas, and tumor tissue from eight "aneuploid" mammary adenocarcinomas. Compared with non-neoplastic mammary epithelium, a slight numerical net non-neoplastic mammary epithelium, a slight numerical net increase of the protein spots was detected in "diploid" tumors and a marked increase in "aneuploid" tumors. Two prominent spots were present in all 16 malignant tissues examined and absent in all eight non-neoplastic tissues (silver staining method). The results suggest that a difference in the composition of cellular proteins exists both between non-neoplastic mammary cells and malignant tumor cells, and between "diploid" and "aneuploid" tumors. |
| Databáze: | OpenAIRE |
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