Fasting Increases Tobramycin Oral Absorption in Mice
| Autor: | Noelia Malusà, Luigina De Leo, Alessandro Ventura, Giuliana Decorti, Tarcisio Not, Nicola Di Toro |
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| Přispěvatelé: | De Leo, L, Di Toro, N, Decorti, Giuliana, Malusà, N, Ventura, Alessandro, Not, Tarcisio |
| Rok vydání: | 2010 |
| Předmět: |
Male
mice TOBRAMYCIN ORAL Administration Oral Biological Availability tobramycin Pharmacology Injections Intramuscular Rhamnose Intestinal absorption Mice Lactulose Pharmacokinetics Oral administration FASTING Tobramycin Animals Medicine Pharmacology (medical) Antibacterial agent Mice Inbred BALB C business.industry Aminoglycoside Fasting Anti-Bacterial Agents Bioavailability Infectious Diseases Intestinal Absorption Injections Intravenous business medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 54:1644-1646 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01172-09 |
| Popis: | The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test with lactulose and l -rhamnose confirmed increased small bowel permeability via the paracellular route in fasting animals. When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate. |
| Databáze: | OpenAIRE |
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