A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites
| Autor: | van den Berg, Thea, Yalamanchili, Kavya, de Gernier, Hugues, Santos Teixeira, Joana, Beeckman, Tom, Scheres, Ben, Willemsen, Viola, Ten Tusscher, Kirsten, Theoretical Biology and Bioinformatics, Sub Theoretical Biology |
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| Přispěvatelé: | Theoretical Biology and Bioinformatics, Sub Theoretical Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
computational modeling
Periodicity Arabidopsis Gene Expression Plant Developmental Biology lateral root priming Biochemistry Plant Roots INITIATION Plant Growth Regulators Gene Expression Regulation Plant Somitogenesis NETWORK periodic developmental patterning root growth dynamics food and beverages Phyllotaxis ARABIDOPSIS SEGMENTATION CLOCK Laboratory of Molecular Biology Signal Transduction EXPRESSION oscillatory priming dynamics Meristem CELL-DIVISION Biology Models Biological General Biochemistry Genetics and Molecular Biology experimental validation Laboratorium voor Moleculaire Biologie Molecular Biology Body Patterning Indoleacetic Acids Mechanism (biology) Biochemistry Genetics and Molecular Biology(all) Arabidopsis Proteins Lateral root Root meristem growth auxin transport Biology and Life Sciences Computational Biology BASAL MERISTEM Cell Biology SELF-ORGANIZATION plant root branching GENE Multicellular organism Biophysics Lateral root branching EPS Developmental biology Genetics and Molecular Biology(all) Developmental Biology |
| Zdroj: | Developmental Cell, 56(15), 2176-2191.e10 Developmental Cell 56 (2021) 15 DEVELOPMENTAL CELL Developmental Cell, 56(15), 2176. Cell Press |
| ISSN: | 1534-5807 1878-1551 |
| Popis: | Modular, repetitive structures are a key component of complex multicellular body plans across the tree of life. Typically, these structures are prepatterned by temporal oscillations in gene expression or signaling. Although a clock-and-wavefront mechanism was identified and plant leaf phyllotaxis arises from a Turing-type patterning for vertebrate somitogenesis and arthropod segmentation, the mechanism underlying lateral root patterning has remained elusive. To resolve this enigma, we combined computational modeling with in planta experiments. Intriguingly, auxin oscillations automatically emerge in our model from the interplay between a reflux-loop-generated auxin loading zone and stem-cell-driven growth dynamics generating periodic cell-size variations. In contrast to the clock-and-wavefront mechanism and Turing patterning, the uncovered mechanism predicts both frequency and spacing of lateral-root-forming sites to positively correlate with root meristem growth. We validate this prediction experimentally. Combined, our model and experimental results support that a reflux-and-growth patterning mechanism underlies lateral root priming. |
| Databáze: | OpenAIRE |
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