Dose–Response Effect of Antibodies to S100 Protein and Cannabinoid Receptor Type 1 in Released-Active Form in the Light–Dark Test in Mice
| Autor: | Elena V. Kardash, Vladimir Ivashkin, Emile Andriambeloson, Sergey A. Tarasov, Stéphanie Wagner, Andrey N. Kolyadin, I. A. Ertuzun, Oleg I. Epstein, Gulnara Rinatovna Khakimova |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
mice antibody-based drugs medicine.drug_class Health Toxicology and Mutagenesis Pharmacology Toxicology Anxiolytic S100 protein nicotine addiction 03 medical and health sciences 0302 clinical medicine Animal model Response effect released-activity cannabinoid receptor antagonists Cannabinoid receptor type 1 medicine Chemical Health and Safety biology Chemistry animal model lcsh:RM1-950 Public Health Environmental and Occupational Health anxiety Nicotine Addiction lcsh:Therapeutics. Pharmacology 030104 developmental biology biology.protein Cannabinoid receptor antagonist Original Article dose–response Antibody 030217 neurology & neurosurgery |
| Zdroj: | Dose-Response Dose-Response, Vol 16 (2018) |
| ISSN: | 1559-3258 |
| Popis: | Earlier studies have shown that combination of antibodies to S100 protein and to cannabinoid receptor type 1 in released-active form (Brizantin) may possess anxiolytic properties and decrease nicotine dependence. Released-active form of antibodies is a novel approach that permits to modify natural functions of the target molecule (antigen) under investigation. The aim of the present study was to evaluate the anxiolytic-like effect of Brizantin in the light–dark test in mice, according to its ability to influence the number of entries into the lit compartment and the total time spent there. Three doses of Brizantin (2.5, 5, and 10 mL/kg) were compared with diazepam (1 mg/kg), placebo, and vehicle control. Anxiolytic-like effect of the tested drug was shown to be dose dependent, with an increasing trend from 2.5 to 10 mL/kg. Brizantin in its highest dose significantly increased studied behavioral parameters, although its effect was less pronounced than that of the reference drug diazepam (1 mg/kg). |
| Databáze: | OpenAIRE |
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