Efficacy generated by afatinib in a lung adenocarcinoma patient harboring HER2 S310Y mutation
| Autor: | Jing Liu, Jian Wang, Peikun Ding, Guanggui Ding, Lin Yang, Lu Zhang, Yuxin Wen, Tengfei Zhang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Radiofrequency ablation Afatinib medicine.medical_treatment Adenocarcinoma of Lung Antineoplastic Agents law.invention Targeted therapy Metastasis 03 medical and health sciences Exon 0302 clinical medicine law Internal medicine Humans Medicine Pharmacology Bedside to Bench Report Lung business.industry medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Mutation Molecular Medicine Adenocarcinoma business Progressive disease medicine.drug |
| Zdroj: | Cancer Biology & Therapy. 19:450-453 |
| ISSN: | 1555-8576 1538-4047 |
| Popis: | Afatinib exhibits therapeutic efficacy for lung adenocarcinoma patients harboring HER2 exon 20 insertions. HER2 S310Y single site substitution was discovered in recent years and afatinib efficacy for adenocarcinoma patients harboring S310Y mutation has not been reported. We presented a case of a 41-year-old male patient with lung adenocarcinoma harboring the HER2 S310Y mutation obtained clinical response to the treatment of afatinib, an oral HER family blocker. After the treatment of afatinib, the patient achieved partial response (PR) in chest lesions and almost complete response (CR) in intracranial lesions. He experienced progressive disease (PD) with liver metastasis and achieved a progression-free survival (PFS) of 5 months. He continually treated with afatinib after CT guided percutaneous radiofrequency ablation to eradicate the hepatic tumor cells and achieved stable disease (SD). In this study, we reported the first clinical evidence of efficacy generated by afatinib, the irreversible HER family inhibitor, targeting HER2 S310Y single site mutation in lung adenocarcinoma. |
| Databáze: | OpenAIRE |
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