Hormone replacement therapy in cancer survivors: utopia?
| Autor: | Corrado Terranova, Francesco Plotti, Pierluigi Benedetti Panici, Roberto Angioli, Salvatore Lopez, Giuseppe Scaletta, Grazia Armento, Alessandra Gatti, Stella Capriglione, Daniela Luvero, Roberto Montera, Giovan Battista Serra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Population Osteoporosis Breast Neoplasms Disease Carcinoma Ovarian Epithelial breast cancer cancer survivors endometrial cancer hormone replacement therapy ovarian cancer risk of gynecological cancers breast neoplasms disease progression endometrial neoplasms estrogen replacement therapy 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Utopias Informed consent Internal medicine medicine Humans Neoplasms Glandular and Epithelial education Ovarian Neoplasms education.field_of_study 030219 obstetrics & reproductive medicine business.industry Estrogen Replacement Therapy Cancer Estrogens Hormone replacement therapy (menopause) Hematology medicine.disease Endometrial Neoplasms Oncology Estrogen 030220 oncology & carcinogenesis Hot Flashes Disease Progression Female Menopause Neoplasm Recurrence Local business |
| Popis: | As growing of old women population, menopausal women will also increase: an accurate estimation of postmenopausal population is an essential information for health care providers considering that with aging, the incidence of all cancers is expected to increase. Hormone replacement therapy (HRT) has proven to be highly effective in alleviating menopausal symptoms such as hot flashes, night sweats, dyspareunia, sexual disorders, and insomnia and in preventing osteoporosis. According to preclinical data, estrogen and progesterone are supposed to be involved in the induction and progression of breast and endometrial cancers. Similarly, in epithelial ovarian cancer (EOC), the pathogenesis seems to be at least partly hormonally influenced. Is HRT in gynecological cancer survivors possible? The literature data are controversial. Many clinicians remain reluctant to prescribe HRT for these patients due to the fear of relapse and the risk to develop coronary heart disease or breast cancer. Before the decision to use HRT an accurate counselling should be mandatory in order to individualizing on the basis of potential risks and benefits, including a close follow-up. Nevertheless, we do believe that with strong informed consent doctors may individually consider to prescribe some course of HRT in order to minimize menopausal symptoms and disease related to hormonal reduction. |
| Databáze: | OpenAIRE |
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