99mTc-MAG3 Diuretic Renography: Intra- and Inter-Observer Repeatability in the Assessment of Renal Function
Autor: | Monika Marti, Christos Sachpekidis, Ali Afshar-Oromieh, Annette Kopp-Schneider, Georgia Keramida, Robin Schepers, Ian Alberts, Axel Rominger |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_treatment
Clinical Biochemistry Renal function 610 Medicine & health Article 030218 nuclear medicine & medical imaging 99mTc-MAG3 03 medical and health sciences 0302 clinical medicine Cohen's kappa medicine repeatability 99mTc MAG3 Left kidney lcsh:R5-920 intra-observer inter-observer business.industry Limits of agreement Repeatability Concordance correlation coefficient 030220 oncology & carcinogenesis diuretic renography Diuretic Nuclear medicine business lcsh:Medicine (General) |
Zdroj: | Diagnostics; Volume 10; Issue 9; Pages: 709 Diagnostics Diagnostics, Vol 10, Iss 709, p 709 (2020) Sachpekidis, Christos; Schepers, Robin; Marti, Monika; Kopp-Schneider, Annette; Alberts, Ian; Keramida, Georgia; Afshar-Oromieh, Ali; Rominger, Axel (2020). 99mTc-MAG3 Diuretic Renography: Intra-and Inter-Observer Repeatability in the Assessment of Renal Function. Diagnostics, 10(9) MDPI 10.3390/diagnostics10090709 |
ISSN: | 2075-4418 |
DOI: | 10.3390/diagnostics10090709 |
Popis: | The aim of the present study is to evaluate the intra- and inter-observer agreement in assessing the renal function by means of 99mTc-MAG3 diuretic renography. One hundred and twenty adults were enrolled in the study. One experienced and one junior radiographer processed the renograms twice by assigning manual and semi-automated regions of interest. The differential renal function (DRF, %), time to maximum counts for the right and left kidney (TmaxR-TmaxL, min) and time to half-peak counts (T1/2, min) were calculated. The Bland–Altman analysis (bias±95% limits of agreement), Lin’s concordance correlation coefficient and weighted Fleiss’ kappa coefficient were used to assess agreement. Based on the Bland–Altman analysis, the intra-observer repeatability results for the experienced radiographer using the manual and the semi-automated techniques were 0.2 ± 2.6% and 0.3 ± 6.4% (DRF), respectively, −0.01 ± 0.24 and 0.00 ± 0.34 (TmaxR), respectively, and 0.00 ± 0.26 and 0.00 ± 0.33 (TmaxL), respectively. For the junior radiographer, the respective results were 0.5 ± 5.0% and 0.8 ± 9.4% (DRF), 0.00 ± 0.44 and 0.01 ± 0.28 (TmaxR), and 0.01 ± 0.28 and −0.02 ± 0.44 (TmaxL). The inter-observer repeatability for the manual method was 0.6 ± 5.0% (DRF), −0.10 ± 0.42 (TmaxR) and −0.05 ± 0.38 (TmaxL), and for the semi-automated method −0.2 ± 9.1% (DRF), 0.00 ± 0.31 (TmaxR) and −0.05 ± 0.40 (TmaxL). The weighted Fleiss’ kappa coefficient for the T1/2 assessments ranged between 0.85–0.97 for both intra- and inter-observer repeatability with both methods. These findings suggest a very good repeatability in DRF assessment with the manual method—especially for the experienced observer—but a less good repeatability with the semi-automated approach. The calculation of Tmax was also operator-dependent. We conclude that reader experience is important in the calculation of renal parameters. We therefore encourage reader training in renal scintigraphy. Moreover, the manual tool seems to perform better than the semi-automated tool. Thus, we encourage cautious use of automated tools and adjunct validation by manual methods where possible. |
Databáze: | OpenAIRE |
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