Red grape (Vitis vinifera L.) flavonoids down-regulate collagen type III expression after UV-A in primary human dermal blood endothelial cells

Autor:	Riccardo G. Borroni, Giovanni Borroni, Serena Di Francesco, Nora Bloise, Monica Savio, Lucia Anna Stivala
Rok vydání:	2018
Předmět:	0301 basic medicine Cell type Antioxidant Cell Survival Ultraviolet Rays medicine.medical_treatment Gene Expression Dermatology Biochemistry Catechin Extracellular matrix 03 medical and health sciences chemistry.chemical_compound Collagen Type III 0302 clinical medicine Flavonols medicine Humans Vitis heterocyclic compounds Molecular Biology Cells Cultured Skin Flavonoids chemistry.chemical_classification Plant Extracts fungi Endothelial Cells food and beverages Intercellular Adhesion Molecule-1 Malvidin Up-Regulation 030104 developmental biology chemistry Pyrimidine Dimers Fruit 030220 oncology & carcinogenesis Quercetin Reactive Oxygen Species
Zdroj:	Experimental Dermatology. 27:973-980
ISSN:	0906-6705
DOI:	10.1111/exd.13682
Popis:	Red grape (Vitis vinifera L.) flavonoids including flavan-3-ols (eg, catechin and epicatechin), flavonols (eg, quercetin) and anthocyanins (eg, malvidin) exert anti-inflammatory and antioxidant activities. In the skin they also have a photoprotective action, and their effects have been extensively investigated in keratinocytes, melanocytes and fibroblasts. Despite their known effects also on blood vasculature, little is known on their activities on human dermal blood endothelial cells (HDBECs), which are critically involved in skin homeostasis as well as in the pathogenesis of neoplastic and inflammatory skin diseases. We sought to study the biological effects of selected red grape flavonoids in preventing the consequences of ultraviolet (UV)-A irradiation in vitro. Our results show that red grape flavonoids prevent UV-A-induced sICAM-1 release in HDBECs, suggesting that this cell type could represent an additional target of the anti-inflammatory activity of flavonoids. In addition, flavonoids effectively inhibited UV-A-induced synthesis of collagen type III at both RNA and protein level, indicating that dermal blood microvasculature could be actively involved in ECM remodelling as a consequence of skin photo-ageing, and that this can be prevented by red grape flavonoids.
Databáze:	OpenAIRE
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