Cell cycle regulation of Golgi membrane dynamics
| Autor: | Yanzhuang Wang, Danming Tang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Golgi membrane
Membrane Glycoproteins Endosome Cell Cycle Golgi ribbon formation Golgi Apparatus Golgi Matrix Proteins Membrane Proteins Cell Biology Cell plate Golgi apparatus Biology Membrane Fusion Article Cell biology symbols.namesake Protein Transport Golgi membrane fusion symbols Golgi cisterna Humans sense organs Ubiquitins Secretory pathway |
| Zdroj: | Trends in cell biology. 23(6) |
| ISSN: | 1879-3088 |
| Popis: | The Golgi apparatus is a membranous organelle in the cell that plays essential roles in protein and lipid trafficking, sorting, processing, and modification. Its basic structure is a stack of closely aligned flattened cisternae. In mammalian cells, dozens of Golgi stacks are often laterally linked into a ribbon-like structure. Biogenesis of the Golgi during cell division occurs through a sophisticated disassembly and reassembly process that can be divided into three distinct but cooperative steps, including the deformation and reformation of the Golgi cisternae, stacks, and ribbon. Here, we review our current understanding of the protein machineries that control these three steps in the cycle of mammalian cell division: GRASP65 and GRASP55 in Golgi stack and ribbon formation; ubiquitin and AAA ATPases in postmitotic Golgi membrane fusion; and golgins and cytoskeleton in Golgi ribbon formation. |
| Databáze: | OpenAIRE |
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