Aromatic amino acids and modification of parkinsonism
| Autor: | Schiffer Lm, George C. Cotzias, Van Woert Mh |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Adult
Male Phenylalanine Substantia nigra Melanin Placebos chemistry.chemical_compound Extrapyramidal syndromes Aromatic amino acids Medicine Humans Melanocyte-Stimulating Hormones Tyrosine Aged Clinical Trials as Topic Manganese business.industry Parkinsonism Bone Marrow Examination Parkinson Disease General Medicine Middle Aged medicine.disease Dihydroxyphenylalanine nervous system chemistry Biochemistry Female business Melanin pigment Agranulocytosis |
| Zdroj: | The New England journal of medicine. 276(7) |
| ISSN: | 0028-4793 |
| Popis: | THE known biochemical abnormalities in Parkinson's disease consist of a decrease of melanin pigment in the substantia nigra1 , 2 and a decrease of some biogenic amines in the substantia nigra and the corpus striatum.3 These 2 defects might be interrelated, as suggested by the fact that in both melanocytes4 and sympathetic cells5 tyrosine is hydroxylated to dihydroxyphenylalanine, a common precursor in the synthesis of both melanin and catecholamines. Furthermore, both melanocytes and sympathetic cells originate from the neural crest.6 It was suggested earlier7 , 8 that the interrelations between melanogenesis and extrapyramidal disease might be of fundamental importance. It was noted that chronic . . . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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