A study of the dosage and duration for levobupivacaine infusion by the caudal‐epidural route in infants aged 3‐6 months
| Autor: | Leon Aarons, Kayode Ogungbenro, Ijeoma Okonkwo, Rita Vashisht, Anju A. Bendon, Adam S. Darwich, Catherine Fullwood, Davandra Patel |
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| Rok vydání: | 2018 |
| Předmět: |
Anesthesia
Epidural medicine.drug_class caudal-epidural infusion levobupivacaine Loading dose 03 medical and health sciences 0302 clinical medicine Racemic bupivacaine Pharmacokinetics 030202 anesthesiology 030225 pediatrics Humans Medicine Pediatrics Perinatology and Child Health Prospective Studies Anesthetics Local Levobupivacaine Pain Measurement Pain Postoperative infants business.industry Local anesthetic α -acid glycoprotein Bladder Exstrophy Infant Orosomucoid Serum concentration Analgesia Epidural Anesthesiology and Pain Medicine Anesthesia Pediatrics Perinatology and Child Health Caudal epidural business bladder exstrophy pharmacokinetics Bladder exstrophy repair medicine.drug |
| Zdroj: | Vashisht, R, Bendon, A, Okonkwo, I, Patel, D, Fullwood, C, Ogungbenro, K, Aarons, L & Darwich, A 2019, ' A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months ', Pediatric Anesthesia, vol. 29, no. 2, pp. 161-168 . https://doi.org/10.1111/pan.13548 |
| ISSN: | 1460-9592 1155-5645 |
| DOI: | 10.1111/pan.13548 |
| Popis: | AimTo investigate total serum levobupivacaine concentrations after a caudal‐epidural loading dose followed by a maintenance infusion in infants aged 3‐6 months over 48 hours.BackgroundThe local anaesthetic, levobupivacaine, is the safer enantiomer of racemic bupivacaine. Present protocols for levobupivacaine are based on studies and pharmacokinetic modelling with racemic bupivacaine. This study will inform clinical practice in this age group and validate the pharmacokinetic model for levobupivacaine infusions in infants, aged 3‐6months.MethodsThe clinical trial was conducted in 8 infants aged 3‐6 months, undergoing bladder exstrophy repair. Pharmacokinetic modelling allowed optimisation of clinical sampling to measure total levobupivacaine and α1‐acid glycoprotein and prediction of the effect of α1‐acid glycoprotein on levobupivacaine plasma protein binding.ResultsThe observed median total levobupivacaine serum concentration was 0.30 mg.L−1 (range: 0.20‐0.70 mg.L−1) at 1 hour after the loading dose of 2 mg.kg−1. The median total levobupivacaine concentration after 47 hours of infusion, at 0.2 mg.h−1.kg−1, was 1.21 mg.L−1 (0.07‐1.85 mg.L−1). Concentrations of α1‐acid glycoprotein were found to rise throughout the study period. Pharmacokinetic modelling suggested that unbound levobupivacaine quickly reached steady state at a concentration of approximately 0.03 mg.L−1.ConclusionThis study examines the pharmacokinetics of levobupivacaine after a loading dose (given over 5 minutes) followed by a maintenance infusion in infants 3‐6 months. The study allows the development of a pharmacokinetic model, combining levobupivacaine and α1‐acid glycoprotein data. Modelling indicates that unbound levobupivacaine quickly reaches steady state once the infusion is started. Simulations suggest that it may be possible to continue the infusion beyond 48 hours. |
| Databáze: | OpenAIRE |
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