Estimation of inbreeding depression on female fertility in the Finnish Ayrshire population
| Autor: | Katja Martikainen, Anna-Maria Tyrisevä, Jukka Pösö, Pekka Uimari, Kaarina Matilainen |
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| Přispěvatelé: | University of Helsinki, Department of Agricultural Sciences, Animal Science Research |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
PEDIGREE Population Ice calving inbreeding SNP Single-nucleotide polymorphism Runs of Homozygosity Biology Insemination Polymorphism Single Nucleotide 03 medical and health sciences Quantitative Trait Heritable Animal science Food Animals HOLSTEIN Inbreeding depression Animals education 412 Animal science dairy science Finland Dairy cattle 2. Zero hunger Genetics fertility education.field_of_study runs of homozygosity Reproduction Genomics General Medicine PERFORMANCE Phenotype 030104 developmental biology cattle Female Animal Science and Zoology DAIRY-CATTLE Inbreeding JERSEYS TRAITS inbreeding depression |
| Popis: | Single nucleotide polymorphism (SNP) data enable the estimation of inbreeding at the genome level. In this study, we estimated inbreeding levels for 19,075 Finnish Ayrshire cows genotyped with a low-density SNP panel (8K). The genotypes were imputed to 50K density, and after quality control, 39,144 SNPs remained for the analysis. Inbreeding coefficients were estimated for each animal based on the percentage of homozygous SNPs (F-PH), runs of homozygosity (F-ROH) and pedigree (F-PED). Phenotypic records were available for 13,712 animals including non-return rate (NRR), number of inseminations (AIS) and interval from first to last insemination (IFL) for heifers and up to three parities for cows, as well as interval from calving to first insemination (ICF) for cows. Average F-PED was 0.02, F-ROH 0.06 and F-PH 0.63. A correlation of 0.71 was found between F-PED and F-ROH, 0.66 between F-PED and F-PH and 0.94 between F-ROH and F-PH. Pedigree-based inbreeding coefficients did not show inbreeding depression in any of the traits. However, when F-ROH or F-PH was used as a covariate, significant inbreeding depression was observed; a 10% increase in F-ROH was associated with 5days longer IFL0 and IFL1, 2weeks longer IFL3 and 3days longer ICF2 compared to non-inbred cows. |
| Databáze: | OpenAIRE |
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