Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia with Aminocaproic Acid
| Autor: | Luis A. Logrono, Genevieve A. Morelli, Hussain I. Saba |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
Chemotherapy Gastrointestinal bleeding Gastrointestinal tract medicine.medical_specialty Vascular disease business.industry medicine.medical_treatment Autosomal dominant trait General Medicine medicine.disease Gastroenterology medicine.anatomical_structure Internal medicine medicine Aminocaproic acid medicine.symptom business Telangiectasia Nose medicine.drug |
| Zdroj: | New England Journal of Medicine. 330:1789-1790 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm199406233302504 |
| Popis: | Hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease) is characterized by telangiectatic lesions of the nose, lips, and visceral organs including the liver, spleen, gastrointestinal tract, lungs, brain, and spinal cord1–5. It is inherited as an autosomal dominant trait. Its most common manifestations are recurrent epistaxis and gastrointestinal bleeding, which can be life threatening6. Nasal bleeding has been treated by dermatoplasty of the nasal septa, photocoagulation, and amniotic-membrane grafts6,7 and by the administration of estrogen and progesterone,8,9 but these treatments are often ineffective. Aminocaproic acid is a potent inhibitor of the fibrinolytic system. In low doses it blocks . . . |
| Databáze: | OpenAIRE |
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