Obstructive jaundice, a rare presentation of lung cancer: A case report
| Autor: | Usha Trivedi, Thomas G Ng, Konstantinos Damiris, Jason C. George |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung adenocarcinoma Pathology medicine.medical_specialty P63 Tumor Protein 63 TTF-1 Thyroid Transcription Factor – 1 Case Report 03 medical and health sciences Diseases of the respiratory system 0302 clinical medicine Thyroid transcription factor 1 Medicine Lung cancer Lung Common bile duct RC705-779 business.industry Pancreatic metastasis Cytokeratin 7 Malignant obstructive jaundice Rare metastasis Jaundice medicine.disease Elevated alkaline phosphatase CNS Central Nervous System medicine.anatomical_structure 030228 respiratory system CK Cytokeratin 030220 oncology & carcinogenesis Vomiting Adenocarcinoma medicine.symptom business Pancreas CK-7 Cytokeratin – 7 |
| Zdroj: | Respiratory Medicine Case Reports, Vol 33, Iss, Pp 101425-(2021) Respiratory Medicine Case Reports |
| ISSN: | 2213-0071 |
| Popis: | Lung cancer metastases to the pancreas are rare but potentially life-threatening. Oftentimes, the presence of symptoms is indicative of extensive disease burden. This report describes a case of primary lung adenocarcinoma metastasizing to the head of the pancreas presenting as obstructive jaundice. The patient was a 61-year-old female veteran who presented with a chronic dyspnea, weight loss, and 3-weeks of nausea and vomiting found to have jaundice, elevated alkaline phosphatase levels, hyperbilirubinemia, and transaminitis. Imaging of her chest revealed large pulmonary parenchymal nodules throughout both lungs with a large left lower lobe mass and consolidation. Abdominal imaging showed a large heterogeneous mass in the pancreatic head, a grossly dilated common bile duct, and enlarged retroperitoneal lymph nodes contiguous with the mass. Pancreatic head biopsies revealed metastatic cancer cells from her lung adenocarcinoma which was confirmed via cytology and the presence of thyroid transcription factor − 1 and cytokeritin-7 expression and the absence of tumor protein 63 staining. Lung adenocarcinomas commonly metastasize to the bones, liver, and central nervous system but very rarely to the pancreas. There have been only a few reported cases of pancreatic tumors that manifested clinically as a result of primary lung cancer metastases however, even though uncommon, hematogenous spread of cancerous tissue should be considered on the differential as a cause for obstructive jaundice in the setting of lung adenocarcinoma. |
| Databáze: | OpenAIRE |
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