Continuous and interval training attenuate encephalomyelitis by separate immunomodulatory mechanisms
| Autor: | Liel Hamdi, Sofia Zoidou, Tamir Ben-Hur, Hanan Nabat, Olga Touloumi, Ofira Einstein, Yehuda Goldberg, Abram Katz, Yifat Zaychik, Nina Fainstein, Nikolaos Grigoriadis, Jay R. Hoffman, Shir Segal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Encephalomyelitis Autoimmune Experimental Encephalomyelitis T cell Inflammation medicine.disease_cause Autoimmunity 03 medical and health sciences Mice 0302 clinical medicine Immune system immune system diseases Physical Conditioning Animal medicine Animals Research Articles business.industry General Neuroscience Experimental autoimmune encephalomyelitis Immunology in the medical area medicine.disease 030104 developmental biology medicine.anatomical_structure Spinal Cord Immunologi inom det medicinska området Immunology Cytokine secretion Female Neurology (clinical) Lymph Nodes medicine.symptom business High-intensity interval training 030217 neurology & neurosurgery Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Popis: | Background Studies have reported beneficial effects of exercise training on autoimmunity, and specifically on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, it is unknown whether different training paradigms affect disease course via shared or separate mechanisms. Objective To compare the effects and mechanism of immune modulation of high intensity continuous training (HICT) versus high intensity interval training (HIIT) on systemic autoimmunity in EAE. Methods We used the proteolipid protein (PLP)-induced transfer EAE model to examine training effects on the systemic autoimmune response. Healthy mice performed HICT or HIIT by running on a treadmill. Lymph-node (LN)-T cells from PLP-immunized trained- versus sedentary donor mice were transferred to naive recipients and EAE clinical and pathological severity were assessed. LN cells derived from donor trained and sedentary PLP-immunized mice were analyzed in vitro for T-cell activation and proliferation, immune cell profiling, and cytokine mRNA levels and cytokine secretion measurements. Results Both HICT and HIIT attenuated the encephalitogenicity of PLP-reactive T cells, as indicated by reduced EAE clinical severity and inflammation and tissue pathology in the central nervous system, following their transfer into recipient mice. HICT caused a marked inhibition of PLP-induced T-cell proliferation without affecting the T-cell profile. In contrast, HIIT did not alter T-cell proliferation, but rather inhibited polarization of T cells into T-helper 1 and T-helper 17 autoreactive populations. Interpretation HICT and HIIT attenuate systemic autoimmunity and T cell encephalitogenicity by distinct immunomodulatory mechanisms. |
| Databáze: | OpenAIRE |
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