Genotoxicity evaluation in patients on phenobarbital monotherapy by sister chromatid exchange
| Autor: | Vernon B. Winge, Melissa Pederson, Blanka Schaumann |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocyte medicine.medical_treatment Sister chromatid exchange Biology Toxicology medicine.disease_cause Gastroenterology Epilepsy Internal medicine Cricetinae medicine Animals Humans Lymphocytes Chemotherapy Smoking DNA medicine.disease Pollution medicine.anatomical_structure Anticonvulsant Phenobarbital Immunology Toxicity Sister Chromatid Exchange Genotoxicity medicine.drug |
| Zdroj: | Journal of toxicology and environmental health. 28(3) |
| ISSN: | 0098-4108 |
| Popis: | The potential of phenobarbital to interact with DNA has been studied using the sister chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls. All patients were otherwise healthy individuals, treated chronically with phenobarbital in monotherapy. No statistically significant differences in SCE levels were found between the patient and control groups. Smoking was associated with increased SCE frequencies. The experiment was repeated with five available patients, using a slightly modified methodology. Although different SCE scores were obtained, the results of both tests were comparable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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