Life expectancy without a transplant for status 1A liver transplant candidates
| Autor: | Sommer E. Gentry, Elizabeth A. King, Nicholas L. Wood, Douglas VanDerwerken, Dorry L. Segev |
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| Rok vydání: | 2021 |
| Předmět: |
Transplantation
Deceased donor medicine.medical_specialty Tissue and Organ Procurement Waiting Lists business.industry Patient survival Law legislation Article Liver Transplantation Organ procurement Life Expectancy Life expectancy Immunology and Allergy Medicine Heart Transplantation Humans Pharmacology (medical) business Intensive care medicine |
| Zdroj: | Am J Transplant |
| ISSN: | 1600-6143 |
| Popis: | Status 1A liver transplant candidates are given the highest medical priority for the allocation of deceased donor livers. Organ Procurement and Transplantation Network (OPTN) policy requires physicians to certify that a candidate has a life expectancy without a transplant of less than 7 days for that candidate to be given status 1A. Additionally, candidates receiving status 1A must have one of six medical conditions listed in policy. Using Scientific Registry of Transplant Recipients data from all prevalent liver transplant candidates from 2010 to 2020, we used a bias-corrected Kaplan-Meier model to calculate the survival of status 1A candidates and to determine their life expectancy without a transplant. We found that status 1A candidates have a life expectancy without a transplant of 24 (95% CI 20-46) days-over three times longer than what policy requires for status 1A designation. We repeated the analysis for subgroups of status 1A candidates based on the medical conditions that grant status 1A. We found that none of these subgroups met the life expectancy requirement. Harmonizing OPTN policy with observed data would sustain the integrity of the allocation process. |
| Databáze: | OpenAIRE |
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