Brain Donation by Proxy: Are There Predictors in Neurodegenerative Dementia?

Autor: J López-Álvarez, M Valentí, B González, L Agüera-Ortiz, J Olazarán, A Rábano, B León-Salas, M A Zea-Sevilla, J L Dobato
Rok vydání: 2017
Předmět:
Zdroj: The journal of prevention of Alzheimer's disease. 1(3)
ISSN: 2426-0266
Popis: OBJECTIVES: To describe the frequency and predictors of brain donation by relatives in patients with neurodegenerative dementia. DESIGN: Database review and quantitative analysis. SETTING: The Alzheimer Center Reina Sofia Foundation (ACRSF), a center devoted to the care and research of patients with neurodegenerative dementia. PARTICIPANTS: Patients with signed consent for participation in the ACRSF research program. MEASUREMENTS: A set of 38 demographic, clinical, and social variables related to patient and closest relative, which were collected by the ACRSF multidisciplinary team upon patient admission. RESULTS: Admission data were available for 198 patients who entered the ACRSF research program; 85 of them (42.9%) died during follow-up. Mean age (SD) at admission was 82.3 (6.8) years and 80.8% of the patients were female. Family link between patient and closest relative was spouse or partner (12.0%), son or daughter (74.9%), or other link (13.1%). Brain was obtained from 56 patients (65.9%). Consent by legal representative and patient’s depressive symptoms were more frequent in the donors (p
Databáze: OpenAIRE