Influence of Ionic Strength on Rectal Absorption of Gentamicin Sulfate in the Presence and Absence of Sodium Salicylate
| Autor: | Larry J. Caldwell, Paula S. Leppert, Joseph A. Fix, Patricia A. Porter |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Sodium Salicylate Sodium Biological Availability Pharmaceutical Science chemistry.chemical_element Absorption (skin) Chloride chemistry.chemical_compound medicine Animals Sorbitol Sodium salicylate Chromatography Chemistry Osmolar Concentration Rectum Rats Inbred Strains Rats Bioavailability Gentamicin Sulfate Intestinal Absorption Rectal Absorption Ionic strength Gentamicins medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 72:1134-1137 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600721006 |
| Popis: | The rectal absorption of gentamicin sulfate in rats, both in the presence and absence of sodium salicylate, was facilitated by the use of high ionic strength aqueous formulations. The relative order of effectiveness in promoting gentamicin absorption was sodium dihydrogen phosphate congruent to sodium chloride much greater than potassium chloride, indicating a preferential effect of sodium ions. The increased gentamicin bioavailability in response to sodium salicylate adjuvant activity appeared to be independent of and additive to the increased gentamicin absorption due to high ionic strength conditions. The inability of sorbitol to increase gentamicin bioavailability above control levels indicated that elevated osmotic pressure was not a major determinant of rectal gentamicin absorption. |
| Databáze: | OpenAIRE |
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