Effect of the retention ring-assisted continuous application of riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus

Autor: Chung Young Kim, Mee Kum Kim
Rok vydání: 2018
Předmět:
Male
Accelerated cross-linking
genetic structures
Riboflavin
Corneal collagen cross-linking
Visual Acuity
Cornea
0302 clinical medicine
lcsh:Ophthalmology
Medicine
Photosensitizing Agents
General Medicine
Refractive Errors
medicine.anatomical_structure
Cross-Linking Reagents
Disease Progression
Female
Collagen
Research Article
Adult
Keratoconus
medicine.medical_specialty
Adolescent
Ultraviolet Rays
Ring (chemistry)
03 medical and health sciences
Young Adult
Ophthalmology
Pulsed-light
Humans
Retrospective Studies
business.industry
Disease progression
Corneal cross-linking (CXL)
Corneal Endothelial Cell Loss
medicine.disease
eye diseases
Retention ring
Photochemotherapy
lcsh:RE1-994
Collagen metabolism
030221 ophthalmology & optometry
sense organs
Isotonic Solutions
business
030217 neurology & neurosurgery
Zdroj: BMC Ophthalmology
BMC Ophthalmology, Vol 19, Iss 1, Pp 1-8 (2019)
ISSN: 1471-2415
Popis: Background To investigate the efficacy and safety of the retention ring-assisted continuous application of 0.1% riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus. Methods The medical records of 20 eyes of 18 patients with progressive keratoconus who received collagen cross-linking at Seoul National University Hospital were retrospectively reviewed. Isotonic 0.1% riboflavin was continuously applied for 10 min using an 8.0-mm retention ring before the irradiation and accelerated cross-linking was applied with 30-mW pulsed-ultraviolet light at a wavelength 365 nm for eight minutes (1 s on/1 s off; 30 mW/cm2, cumulative dose of 7 .2J/cm2) without further intermittent application of riboflavin. Visual acuity, refractive error, topographic index, corneal thickness, and endothelial cell density were evaluated before the operation and at 1, 3, 6, and 12 months. Results The best corrected visual acuity in logMAR improved from preoperative 0.43 to 0.17 in 12 months (p = 0.050). Maximum keratometry decreased from 51.8 D to 50.4 D at 6 months (p = 0.015) and 50.1 D at 12 months (p = 0.0003). Astigmatism decreased from preoperative 5.5 D to 4.1 D at 12 months (p 0.05). Endothelial cell density decreased at postoperative 1 month (p = 0.02) but gradually recovered in 12 months (p > 0.05). Conclusions Retention ring-assisted continuous application of riboflavin for 10 minutes in pulsed-light accelerated cross-linking is a comparably safe and effective treatment for halting the progression of keratoconus in 12 months when compared to outcomes of the standard Dresden protocol shown in previous reports. Electronic supplementary material The online version of this article (10.1186/s12886-019-1085-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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