Heart failure – what’s new and what’s changed?
| Autor: | Paul D. Callan, Andrew L. Clark |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
medicine.medical_specialty media_common.quotation_subject Best practice Population Tetrazoles Horizons in Medicine 030204 cardiovascular system & hematology Cardiovascular law.invention Positive-Pressure Respiration Diabetes Complications 03 medical and health sciences Angiotensin Receptor Antagonists Ventricular Dysfunction Left 0302 clinical medicine Randomized controlled trial law Excellence Multidisciplinary approach Medicine Humans 030212 general & internal medicine Intensive care medicine education media_common Aged Randomized Controlled Trials as Topic Aged 80 and over Heart Failure education.field_of_study business.industry Aminobutyrates Biphenyl Compounds General Medicine medicine.disease Sleep Apnea Central Clinical trial Drug Combinations Heart failure Practice Guidelines as Topic Valsartan business Sacubitril Valsartan |
| Popis: | Physicians responsible for the care of patients with heart failure due to left ventricular systolic dysfunction have access to a broad range of evidence-based treatments that prolong life and reduce symptoms. In spite of the significant progress made over the last four decades, there is an ongoing need for novel therapies to treat a condition that is associated with stubbornly high morbidity and mortality. In this article, we discuss the findings of SERVE-HF, a randomised controlled trial of adaptive servo-ventilation in patients with left ventricular systolic dysfunction, as well as EMPA-REG, a study of the effects of a novel diabetic agent that may be of greater interest to heart failure specialists than diabetologists. We also examine further analyses of the groundbreaking PARADIGM-HF trial, which attempt to answer some of the unresolved questions from the original study of the first combined angiotensin-receptor blocker and neprilysin inhibitor, sacubitril valsartan. The recently published National Institute for Health and Care Excellence guidelines for the management of acute heart failure and plans to introduce best practice tariffs bring into focus the need for well-organised, multidisciplinary care. We discuss the challenges involved in developing and delivering a specialist service that meets the needs of a growing population of patients living with heart failure. |
| Databáze: | OpenAIRE |
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