A meta-analysis of genome-wide association studies identifies multiple longevity genes

Autor: Jerome I. Rotter, Rachel Duncan, Lenore J. Launer, Iris E. Jansen, Sarah Cubaynes, Nir Barzilai, Elizabeth J. Becker, Wiesje M. van der Flier, Joris Deelen, Sharon L.R. Kardia, Birgit Debrabant, Wanlin Zheng, Michael A. Province, Janina Dose, Anne B. Newman, Vilmundur Gudnason, Carol Jagger, Kenny Ye, Gil Atzmon, Carmen Martin-Ruiz, Kathryn L. Lunetta, Claudio Franceschi, Marianne Nygaard, Diana van Heemst, Najaf Amin, P. Eline Slagboom, Thomas B. L. Kirkwood, Ilkka Seppälä, Chloé Sarnowski, Heather J. Cordell, Terho Lehtimäki, Jennifer A. Smith, Cornelia M. van Duijn, Marja Jylhä, Dan E. Arking, Hélène Blanché, Jessica D. Faul, Yi Zeng, Henne Holstege, Kent D. Taylor, Junxia Min, Alice M. Arnold, Kristin L. Ayers, Mika Kähönen, Olli T. Raitakari, Pilar Galan, Mary K. Wojczynski, Jean-Marie Robine, Lene Christiansen, David R. Weir, Karen Davies, J. Collerton, Kaare Christensen, Douglas P. Kiel, Niccolò Tesi, Andrew Kingston, Bruce M. Psaty, Joanne M. Murabito, Marcel J. T. Reinders, Albert V. Smith, Xiaomin Liu, Leo-Pekka Lyytikäinen, Mary L. Biggs, Almut Nebel, Sven J. van der Lee, Mikko Hurme, David Karasik, Jean-François Deleuze, Thomas T. Perls, Erin B. Ware, Martijn Huisman, Marian Beekman, Chao Nie, Tamara B. Harris, Ellen A. Nohr, Eric S. Orwoll, Steven R. Cummings, Paola Sebastiani, James W. Vaupel, Wolfgang Lieb, Daniel S. Evans, Thorkild I. A. Sørensen, André G. Uitterlinden, Ashley van der Spek
Přispěvatelé: Max planck Institute for Biology of Ageing [Cologne], Leiden University Medical Center (LUMC), California Pacific Medical Center Research Institute, Johns Hopkins University School of Medicine [Baltimore], McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, Department of Clinical Genetics (Academic Medical Center, University of Amsterdam), VU University Medical Center [Amsterdam], Delft Bioinformatics Lab [Delft], Delft University of Technology (TU Delft), University of Southern Denmark (SDU), Beijing Genomics Institute [Shenzhen] (BGI), China National GeneBank, Division of Statistical Genomics, Washington University School of Medicine, Department of Biostatistics, University of Washington [Seattle], Department of Medicine, Department of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Medicine [Bronx, NY, USA], Albert Einstein College of Medicine [New York], Department of Biology, Faculty of Sciences and Science Education, Haifa University, University of Haifa [Haifa], Institute for Social Research, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Department of Biostatistics [Boston, MA, USA], Harvard T.H. Chan School of Public Health, Icelandic Heart Association [Kopavogur, Iceland] (IHA), Department of Clinical Chemistry, Tempere University, Institute of Genetic Medicine [Newcastle], Newcastle University [Newcastle], Institute of Clinical Molecular Biology, Kiel University, SEMA4, Department of Biostatistics, University of Washington, Boston University [Boston] (BU), Fondation Jean Dausset CEPH, Odense University Hospital, Odense, Copenhagen University Hospital, Institute of Health and Society, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institute of Neuroscience [Newcastle] (ION), Institute of Clinical Research, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute of Ageing and Health, Newcastle University, Newcastle Upon Tyne, Department of Applied Mathematics and Centre of Bioinformatics, Lobachevsky State University [Nizhni Novgorod], Institute of Neurological Sciences of Bologna IRCCS, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Icelandic Heart Association, Heart Preventive Clinic and Research Institute, University of Iceland [Reykjavik], National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Department of Clinical Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, Amsterdam Public Health Research Institute [The Netherlands], Department of Microbiology and Immunology, University of Tampere [Finland], Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Institute of Health & Society, Department of Complex Trait Genetics, Vrije Universiteit Amsterdam [Amsterdam] (VU), Tampere University Hospital, School of Public Health, University of Michigan [Dearborn], Faculty of Medicine and Life Sciences [Tampere], Institute of Epidemiology and Biobank PopGen, Faculty of Medicine and Health Technology [Tampere, Finland], Zhejiang University School of Medicine [China], University of Pittsburgh Graduate School of Public Health, Oregon Health & Sciences University, Oregon Health and Science University [Portland] (OHSU), Boston University School of Medicine (BUSM), Department of Medicine, University of Washington, Department of Epidemiology, University of Washington, Kaiser Permanente Washington Health Research Institute [Seattle] (KPWHRI), Turku University Hospital (TYKS), University of Turku, School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), UCLA Medical Center, University of Michigan System, University of Copenhage, Faculty of Health and Medical Sciences, MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni] (MRC IEU), University of Bristol [Bristol], Los Angeles Biomedical Research Institute (LA BioMed), Harbor UCLA Medical Center [Torrance, Ca.], Netherlands Genomics Initiative, Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), Department of Internal Medicine (ROTTERDAM - Med Int), Maasstad Ziekenhuis = Maasstad Hospital, Alzheimercentre, department of Neurology, VU University Medical Center, Nuffield Department of Population Health [Oxford], University of Oxford, Max Planck Institute for Demographic Research (MPIDR), Max-Planck-Gesellschaft, Beijing Forestry University, Medical School of Duke University, Hinda and Arthur Marcus Institute for Aging Research,Hebrew SeniorLife, Harvard Medical School [Boston] (HMS), Broad Institute of MIT & Harvard, AUDOUX, Michèle, Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), University of California-University of California, Maasstad Hospital, University of Oxford [Oxford], Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Neurology, Amsterdam Neuroscience - Complex Trait Genetics, Human genetics, APH - Personalized Medicine, APH - Methodology, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Epidemiology, Internal Medicine, Universiteit Leiden, École Pratique des Hautes Études (EPHE)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Percentile
Aging
Apolipoprotein E2
media_common.quotation_subject
Science
[SDV]Life Sciences [q-bio]
Longevity
Apolipoprotein E4
Áhættuþættir
General Physics and Astronomy
Genome-wide association study
Diseases
[SDV.GEN] Life Sciences [q-bio]/Genetics
Biology
Genetic correlation
Genome-wide association studies
Article
General Biochemistry
Genetics and Molecular Biology
Odds
03 medical and health sciences
0302 clinical medicine
Genetics
Humans
lcsh:Science
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
media_common
Genetic association
[SDV.GEN]Life Sciences [q-bio]/Genetics
Multidisciplinary
Öldrun
Sjúkdómar
Human Genome
General Chemistry
Genetic architecture
[SDV] Life Sciences [q-bio]
Ageing
030104 developmental biology
Risk factors
Meta-analysis
lcsh:Q
Erfðarannsóknir
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppälä, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanché, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnason, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylhä, M, Kähönen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimäki, T, Lieb, W, Lyytikäinen, L P, Martin-Ruiz, C, Min, J, Nebel, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psaty, B M, Raitakari, O T, Reinders, M J T, Robine, J M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, Taylor, K D, Uitterlinden, A G, van der Flier, W, van der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, no. 1, 3669 . https://doi.org/10.1038/s41467-019-11558-2
Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppälä, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanché, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnason, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylhä, M, Kähönen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimäki, T, Lieb, W, Lyytikäinen, L P, Martin-Ruiz, C, Min, J, Nebel, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psaty, B M, Raitakari, O T, Reinders, M J T, Robine, J M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, Taylor, K D, Uitterlinden, A G, van der Flier, W, van der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 (2019) . https://doi.org/10.1038/s41467-019-11558-2
Nature Communications, 10(1):3669. Nature Publishing Group UK
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1)
Nature communications, vol 10, iss 1
Nature Communications, 10:3669. Nature Publishing Group
Nature Communications, 10
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van Der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppala, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanche, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J-F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnaso, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylha, M, Kahonen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimaki, T, Lieb, W, Lyytikainen, L-P, Martin-Ruiz, C, Min, J, Nebe, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psat, B M, Raitakari, O T, Reinders, M J T, Robine, J-M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, D Taylor, K, Uitterlinden, A G, van Der Flier, W, van Der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 . https://doi.org/10.1038/s41467-019-11558-2
Nat Commun
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11558-2
Popis: Publisher's version (útgefin grein).
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.
Alexander von Humboldt-Stiftung
Databáze: OpenAIRE
Externí odkaz: