Pandanus Alkaloids in Stemonaceae: Finding of a Plausible Biogenetic Origin of Stemona Alkaloids
| Autor: | Srunya Vajrodaya, Lothar Brecker, Otmar Hofer, Harald Greger, Johann Schinnerl |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pyrrolidines
Stemona Tertiary amine Stereochemistry Pandanales Pharmaceutical Science Analytical Chemistry Alkaloids Dioscoreales Drug Discovery Stemonaceae Organic chemistry Spiro Compounds Furans Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Plant Stems biology Chemistry Organic Chemistry Croomia Stereoisomerism biology.organism_classification Plant Leaves Complementary and alternative medicine Stichoneuron Molecular Medicine Pandanaceae |
| Zdroj: | Journal of Natural Products. 72:1708-1711 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np900294c |
| Popis: | The isolation of (Z,Z)-pandanamine (1) and its corresponding isomers (Z,E)-pandanamine (2) and (E,E)-pandanamine (3) from Stichoneuron calcicola of the family Stemonaceae is of outstanding chemosystematic importance. This alkaloid was previously only known from the family Pandanaceae, where it was accompanied by a series of pyrrolidines, collectively called Pandanus alkaloids. The pyrrolidines pandamarilactonines A (4), B (5), C (6), and D (7) were also detected in the present study, most likely representing artificial cyclization products of pandanamine (1-3) formed by acidic conditions during chromatographic separation on silica gel. Similar structures were found in various Stemona alkaloids, suggesting a close relationship between the two plant families. Structurally, pandanamine (1-3) can be regarded as a direct precursor of croomine (8), originally isolated from Croomia, a genus closely related to Stichoneuron, but later also found in various Stemona species. The co-occurrence of pandanamine (1-3), croomine (8), and stichoneurin (9) in the family Stemonaceae represents a sound argument for a new interpretation of the biogenetic origin of Stemona alkaloids and at the same time substantiates the removal of the family from the order Dioscoreales and its inclusion into Pandanales, as already suggested by DNA sequencing. |
| Databáze: | OpenAIRE |
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