Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax)
| Autor: | José L. Zambonino Infante, Jacques Moriceau, Chantal Cahu, Laure Villeneuve, Enric Gisbert |
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| Přispěvatelé: | Nutrition, Aquaculture et Génomique (NUAGE), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Institute of Agrifood Research and Technology (IRTA) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Medicine (miscellaneous)
Bass (fish) chemistry.chemical_compound Morphogenesis Retinoid pathway Trypsin RETINOID PATHWAY Vitamin A ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics biology POLYUNSATURATED FATTY ACID Reverse Transcriptase Polymerase Chain Reaction Abnormalities Drug-Induced Gene Expression Regulation Developmental 04 agricultural and veterinary sciences Hypervitaminosis A Biochemistry Larva Amylases Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Dicentrarchus Polyunsaturated fatty acid BAR COMMUN Vitamin medicine.medical_specialty food.ingredient 03 medical and health sciences food Internal medicine medicine Animals 14. Life underwater Sea bass 030304 developmental biology MORPHOGENESE Retinoic acid receptor gamma Alkaline Phosphatase medicine.disease biology.organism_classification Spine Diet Endocrinology chemistry Sea bass larvae MORPHOGENESIS VITAMIN A 040102 fisheries SEA BASS LARVAE 0401 agriculture forestry and fisheries Bass [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition PUFA |
| Zdroj: | British Journal of Nutrition British Journal of Nutrition, Cambridge University Press (CUP), 2006, 95 (4), pp.677-687. ⟨10.1079/BJN20051668⟩ British Journal of Nutrition (0007-1145) (CABI), 2006-04, Vol. 95, N. 4, P. 677-687 |
| ISSN: | 0007-1145 1475-2662 |
| Popis: | The effect of the feeding period on larval development was investigated in European sea bass larvae by considering the expression level of some genes involved in morphogenesis. Larvae were fed a control diet except during three different periods (period A: from 8 to 13 d post-hatching (dph); period B: from 13 to 18 dph; period C: from 18 to 23 dph) with two compound diets containing high levels of vitamin A or PUFA. European sea bass morphogenesis was affected by these two dietary nutrients during the early stages of development. The genes involved in morphogenesis could be modulated between 8 and 13 dph, and our results indicated that retinoids and fatty acids influenced two different molecular pathways that in turn implicated two different gene cascades, resulting in two different kinds of malformation. Hypervitaminosis A delayed development, reducing the number of vertebral segments and disturbing bone formation in the cephalic region. These malformations were correlated to an upregulation of retinoic acid receptor gamma, retinoid X receptor (RXR) alpha and bone morphogenetic protein (BMP)4. An excess of PUFA accelerated the osteoblast differentiation process through the upregulation of RXR alpha and BMP4, leading to a supernumerary vertebra. These results suggest that the composition of diets devoted to marine fish larvae has a particularly determining effect before 13 dph on the subsequent development of larvae and juvenile fish. |
| Databáze: | OpenAIRE |
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