Twenty years of calcium imaging: cell physiology to dye for
| Autor: | Maud Frieden, Eric A. Sobie, Wolfgang F. Graier, Ismail Laher, Harm J. Knot, W. J. Lederer, Leticia Gómez-Viquez, Long-Sheng Song, Silvia Guatimosim, Roland Malli, Ole H. Petersen, Hali Hartmann |
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| Rok vydání: | 2005 |
| Předmět: |
Cell physiology
Time Factors Context (language use) Biology Endoplasmic Reticulum Models Biological Muscle Smooth Vascular Article Cell Physiological Phenomena Calcium imaging Animals Humans Calcium Signaling Calcium signaling Fluorescent Dyes Endoplasmic reticulum Endothelial Cells Depolarization Epithelial Cells Cell biology Rats Sarcoplasmic Reticulum Molecular Medicine Calcium Signal transduction Homeostasis Signal Transduction |
| Zdroj: | Molecular interventions. 5(2) |
| ISSN: | 1534-0384 |
| Popis: | The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes. |
| Databáze: | OpenAIRE |
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