High cholesterol-supplemented diet during gestation and lactation alters liver glycosaminoglycans and associated lipoprotein receptors and results in fat accumulation in adulthood
| Autor: | Sanjana Jagannath, Nandini D. Chilkunda |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Normal diet Offspring Endocrinology Diabetes and Metabolism Receptor expression Hypercholesterolemia Biology High cholesterol chemistry.chemical_compound Endocrinology Pregnancy Internal medicine Lactation medicine Animals Glycosaminoglycans Receptors Lipoprotein Nutrition and Dietetics Cholesterol medicine.disease Diet Rats medicine.anatomical_structure Liver chemistry Female lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Nutrition Research. 93:50-60 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2021.07.002 |
| Popis: | In utero insults to growing fetus impact its health in adulthood. Glycosaminoglycans (GAGs) are involved in lipoprotein metabolism in the liver and vary both quantitively and qualitatively on feeding adult rats a diet rich in cholesterol. However, no reports are available to show the modulation of GAGs when the offspring are subjected to a high cholesterol diet in gestation and lactation stages. Hypercholesterolemia in pregnant rats was induced by feeding an AIN-93 diet supplemented with 0.5% cholesterol. The pups born to mothers fed with high cholesterol diet showed a significant increase in cholesterol and triglycerides accumulation in the liver. Quantitative changes in sulfated glycosaminoglycans (sGAGs), in particular of heparan sulfate, were observed across the developmental stages. Other players involved in lipoprotein metabolism, namely low-density lipoprotein receptor-related protein 1, apolipoprotein E, and low-density lipoprotein receptor expression levels, also showed differential changes across developmental stages. Interestingly, when pups from hypercholesterolemic mothers were fed a normal diet after weaning until adulthood, a considerable amount of fat accumulation in the liver was observed, implicating fetal exposure to early high cholesterol exposure on long term health. |
| Databáze: | OpenAIRE |
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