Potential early biomarkers of sarcopenia among independent older adults
| Autor: | Yaiza Potes Ochoa, Juan José Solano, Adrián Rubio González, Ignacio Vega Naredo, Jose Antonio Boga, Beatriz Caballero, Marta Martinez Reig, Carlos Bermejo Millo, Luis Romero Rizos, Pedro Manuel Sánchez Jurado, Pedro Abizanda, Ana María Coto Montes |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Sarcopenia medicine.medical_specialty Calorie General Biochemistry Genetics and Molecular Biology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Prevalence medicine Humans 030212 general & internal medicine Aged business.industry Confounding Obstetrics and Gynecology musculoskeletal system medicine.disease body regions Malnutrition Cross-Sectional Studies Endocrinology chemistry Close relationship Blood biomarkers Female Independent Living business human activities Biomarkers 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Maturitas. 104:117-122 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/j.maturitas.2017.08.009 |
| Popis: | Objectives There are no tools or biomarkers for a quantitative analysis of sarcopenia. Study design Cross-sectional study of the diagnosis of sarcopenia in 200 independent adults aged 70 years or over. Main outcome measures Sarcopenia was defined as loss of muscle mass together with low strength and/or loss of physical performance. We considered different clinical parameters and assayed potential blood biomarkers (cell energetic metabolism, muscle performance, inflammation, infection and oxidative stress). Results The prevalence of sarcopenia was 35.3% in women and 13.1% in men, and it was significantly associated with advanced age, a low functional performance in the lower extremities, deficient weekly consumption of kilocalories, risk of malnutrition, and drug use for the digestive system. A close relationship was found between sarcopenia, pre-frailty and depressed mood. With these confounding variables, we observed that products of lipid peroxidation were closely associated with sarcopenia in independent older adults (frail participants and those with severe dependence had been excluded from the sample). The best multivariate model proposed was able to predict 67.6% of the variance in sarcopenia, with a power of discrimination of 93.5%. Additional analyses considering lipid levels, fat mass, dyslipidemia, use of lipid-lowering drugs and hypertension confirmed this close association between lipid peroxidation and sarcopenia. Conclusions Given the difficulty in the diagnosis of sarcopenia in clinical practice, we suggest the use of blood circulating products of lipid peroxidation as potential biomarkers for an early diagnosis of sarcopenia in independent older adults. |
| Databáze: | OpenAIRE |
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