FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

Autor: Christine Denoyelle, Nicolas Cagnard, Vladimir Lazar, Anne Dubart-Kupperschmitt, Georges Bismuth, Stéphanie Fabre, Florent Carrette, David A. Fruman, Marianne Mangeney, Valérie Lang, Jing Chen, Monique Semichon
Přispěvatelé: Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Department of Molecular Biology and Biochemistry, and Center for Immunology, University of California [Irvine] (UCI), Proteomic unit, Centro de Investigacion Cooperativa en Biociencias, Département de la Recherche Clinique et du Développement, Assistance publique - Hôpitaux de Paris (AP-HP), Unité de génomique fonctionnelle, Institut Gustave Roussy (IGR), Garcia, Marie, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), University of California-University of California
Rok vydání: 2008
Předmět:
MESH : Protein Biosynthesis
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
T-Lymphocytes
MESH: Chemotaxis
Leukocyte
MESH : Kruppel-Like Transcription Factors
Phosphatidylinositol 3-Kinases
MESH : 1-Phosphatidylinositol 3-Kinase
Transcriptional regulation
Immunology and Allergy
MESH: L-Selectin
[INFO.INFO-BT]Computer Science [cs]/Biotechnology
L-Selectin
Cells
Cultured
Regulation of gene expression
MESH : Gene Expression Regulation
Forkhead Box Protein O1
MESH : Chemotaxis
Leukocyte
Forkhead Transcription Factors
MESH: Receptors
Lysosphingolipid
MESH: Gene Expression Regulation
Cell biology
MESH : Forkhead Transcription Factors
Chemotaxis
Leukocyte
Receptors
Lysosphingolipid
medicine.anatomical_structure
MESH: Protein Biosynthesis
L-selectin
MESH: Kruppel-Like Transcription Factors
MESH : L-Selectin
hormones
hormone substitutes
and hormone antagonists
MESH: Cells
Cultured
endocrine system
T cell
proliferation
Immunology
Kruppel-Like Transcription Factors
Biology
foxo
MESH: Gene Expression Profiling
Cell quiescence
MESH: Forkhead Transcription Factors
MESH : Cells
Cultured
medicine
Humans
Transcription factor
PI3K/AKT/mTOR pathway
MESH : Receptors
Lysosphingolipid
MESH : T-Lymphocytes
MESH: Humans
MESH : Gene Expression Profiling
Gene Expression Profiling
MESH : Humans
MESH: 1-Phosphatidylinositol 3-Kinase
DNA
human T lymphocytes
Molecular biology
[SDV.BIO] Life Sciences [q-bio]/Biotechnology
MESH: T-Lymphocytes
[INFO.INFO-BT] Computer Science [cs]/Biotechnology
Gene Expression Regulation
Protein Biosynthesis
biology.protein
Homing (hematopoietic)
Zdroj: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 181 (5), pp.2980-9
Journal of Immunology, 2008, 181 (5), pp.2980-9
Scopus-Elsevier
ISSN: 1550-6606
0022-1767
Popis: In T cells, the PI3K pathway promotes proliferation and survival induced by Ag or growth factors, in part by inactivating the FOXO transcription factor 1. We now report that FOXO1 controls the expression of L-selectin, an essential homing molecule, in human T lymphocytes. This control is already operational in unprimed T cells and involves a transcriptional regulation process that requires the FOXO1 DNA-binding domain. Using transcriptional profiling, we demonstrate that FOXO1 also increases transcripts of EDG1 and EDG6, two sphingosine-1-phosphate receptors that regulate lymphocyte trafficking. Additionally, FOXO1 binds the promoter of the cell quiescence and homing regulator Krüppel-like factor 2 and regulates its expression. Together, these results reveal a new function of FOXO1 in the immune system and suggest that PI3K controls a coordinated network of transcription factors regulating both cell quiescence and homing of human T lymphocytes.
Databáze: OpenAIRE
Externí odkaz: