Induced Cardiomyocyte Proliferation: A Promising Approach to Cure Heart Failure
| Autor: | Abou bakr M. Salama, Riham Abou-Leisa, Tamer M.A. Mohamed, Ahmad Gebreil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty QH301-705.5 Cell Plasticity Review 030204 cardiovascular system & hematology Catalysis Inorganic Chemistry Cardiac regeneration 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Humans Regeneration Myocytes Cardiac Biology (General) Physical and Theoretical Chemistry Cardiomyocyte proliferation QD1-999 Molecular Biology Spectroscopy Cell Proliferation Heart Failure business.industry Proliferative capacity Cell Cycle Organic Chemistry cardiac regeneration Human heart Heart General Medicine Cell cycle medicine.disease Computer Science Applications Chemistry 030104 developmental biology Heart Injuries cardiomyocyte proliferation Heart failure Cardiology Heart repair business Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 7720, p 7720 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Unlike some lower vertebrates which can completely regenerate their heart, the human heart is a terminally differentiated organ. Cardiomyocytes lost during cardiac injury and heart failure cannot be replaced due to their limited proliferative capacity. Therefore, cardiac injury generally leads to progressive failure. Here, we summarize the latest progress in research on methods to induce cardiomyocyte cell cycle entry and heart repair through the alteration of cardiomyocyte plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions. |
| Databáze: | OpenAIRE |
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