Relationship between serum interleukin-1β levelsand acute phase response proteins in patients with familial Mediterranean fever
| Autor: | Hulya Uzkeser, Kadir Yildirim, Muhammet Dursun Kaya, Ahmet Kiziltunc, Mustafa Keles, Abdulkadir Yildirim, Saliha Karatay |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty familial Mediterranean fever cytokine IL-1β inflammation medicine.medical_treatment Interleukin-1beta Clinical Biochemistry Familial Mediterranean fever Inflammation Blood Sedimentation Fibrinogen Young Adult Internal medicine Humans Medicine Acute-Phase Reaction biology medicine.diagnostic_test business.industry Biochemistry (medical) C-reactive protein Case-control study Acute-phase protein Middle Aged medicine.disease Original Papers Familial Mediterranean Fever C-Reactive Protein Cytokine Endocrinology Case-Control Studies Erythrocyte sedimentation rate biology.protein Female medicine.symptom business Acute-Phase Proteins medicine.drug |
| Zdroj: | Biochemia Medica Volume 22 Issue 1 |
| ISSN: | 1846-7482 1330-0962 |
| DOI: | 10.11613/bm.2012.012 |
| Popis: | Introduction The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period. Materials and methods The serum levels of IL-1beta, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers. Results Serum IL-1beta levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1beta and CRP (r = 0.513, P = 0.002) values of FMF group. Conclusions In conclusion, our results confirm the presence of increased IL-1beta levels in FMF patients during attack-free period. Serum IL-1beta values seems to correlate with CRP levels. The elevation of IL-1beta levels may be important in monitoring subclinical inflammation of attack free period in FMF patients. |
| Databáze: | OpenAIRE |
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