Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study
| Autor: | Mari Yokoi, Kenichi Suzuki, Takashi Daimon, Kazuyuki Inoue, Masahiko Nakao, Toshihiro Hama, K Takeda, H. Ayuhara, Y. Kogure, Makoto Nishio, Keita Hirai, Toshinobu Hayashi, K Shibata, Daiki Tsuji, Kunihiko Itoh |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Quinuclidines Multivariate analysis ATP Binding Cassette Transporter Subfamily B Genotype medicine.drug_class Antineoplastic Agents Pharmacology Granisetron Polymorphism Single Nucleotide law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Genetics medicine Antiemetic ATP Binding Cassette Transporter Subfamily G Member 2 Humans Aged Cisplatin Univariate analysis business.industry Palonosetron Middle Aged Isoquinolines Neoplasm Proteins Pharmacogenomic Testing 030104 developmental biology Logistic Models 030220 oncology & carcinogenesis Pharmacogenomics Multivariate Analysis Molecular Medicine Antiemetics Female business medicine.drug |
| Zdroj: | The pharmacogenomics journal. 17(5) |
| ISSN: | 1473-1150 |
| Popis: | Resistance to antiemetic treatment with 5-hydroxytryptamine-3 receptor antagonist is an issue. This study evaluated the potential roles of ABCB1 and ABCG2 polymorphisms in antiemetic treatment resistance in patients with cancer previously enrolled in a randomized controlled trial. A total of 156 patients were evaluated for their responses to antiemetic therapy and then subdivided into granisetron or palonosetron groups. The genotypes were evaluated for their association with antiemetic efficacy in each treatment groups. Additional risk factors associated with complete response (CR) were examined using a multivariate regression analysis. No significant associations were identified for genetic polymorphisms in the palonosetron group. In the granisetron group, patients with ABCB1 2677TT and 3435TT genotypes had higher proportion of CR. In addition to ABCB1 polymorphisms, gender and cisplatin dose were associated with granisetron response by univariate analysis. Multivariate logistic regression analysis revealed that the ABCB1 3435C>T polymorphism and cisplatin dose were significant predictors of CR. |
| Databáze: | OpenAIRE |
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