Associations between infection intensity categories and morbidity prevalence in school-age children are much stronger for Schistosoma haematobium than for S. mansoni

Autor: W. Evan Secor, Penelope Vounatsou, Michael D. French, Sake J. de Vlas, Fiona M. Fleming, Darin S. Evans, Jürg Utzinger, Ryan E. Wiegand, Charles H. King, Susan P. Montgomery, Arminder K Deol
Přispěvatelé: Public Health
Rok vydání: 2021
Předmět:
Male
Schistosoma Mansoni
Physiology
Eggs
RC955-962
Urine
Schistosomiasis haematobia
Medical Conditions
Reproductive Physiology
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Schistosomiasis
Microhematuria
Child
Urinary Tract
Schistosoma haematobium
biology
Eukaryota
Body Fluids
Diarrhea
Infectious Diseases
Liver
Helminth Infections
Schistosoma
Female
Schistosoma mansoni
medicine.symptom
Anatomy
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
medicine.medical_specialty
Adolescent
Bladder
Chemoprevention
Veins
SDG 3 - Good Health and Well-being
Internal medicine
Helminths
parasitic diseases
medicine
Parasitic Diseases
Animals
Humans
Multiple morbidities
Portal Veins
Parasite Egg Count
Africa South of the Sahara
business.industry
Public Health
Environmental and Occupational Health
Organisms
Biology and Life Sciences
Renal System
biology.organism_classification
medicine.disease
Tropical Diseases
medicine.icd_9_cm_classification
Invertebrates
Schistosoma Haematobium
Schistosomiasis mansoni
Health Care
Tanzania
Cardiovascular Anatomy
Blood Vessels
Morbidity
Health Statistics
business
Zoology
Zdroj: PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009444 (2021)
PLoS Neglected Tropical Diseases, 15(5):e0009444. Public Library of Science
PLoS Neglected Tropical Diseases
ISSN: 1935-2727
DOI: 10.5451/unibas-ep89621
Popis: Background World Health Organization (WHO) guidelines for measuring global progress in schistosomiasis control classify individuals with Schistosoma spp. infections based on the concentration of excreted eggs. We assessed the associations between WHO infection intensity categories and morbidity prevalence for selected S. haematobium and S. mansoni morbidities in school-age children. Methodology A total of 22,488 children aged 6–15 years from monitoring and evaluation cohorts in Burkina Faso, Mali, Niger, Uganda, Tanzania, and Zambia from 2003–2008 were analyzed using Bayesian logistic regression. Models were utilized to evaluate associations between intensity categories and the prevalence of any urinary bladder lesion, any upper urinary tract lesion, microhematuria, and pain while urinating (for S. haematobium) and irregular hepatic ultrasound image pattern (C-F), enlarged portal vein, laboratory-confirmed diarrhea, and self-reported diarrhea (for S. mansoni) across participants with infection and morbidity data. Principal findings S. haematobium infection intensity categories possessed consistent morbidity prevalence across surveys for multiple morbidities and participants with light infections had elevated morbidity levels, compared to negative participants. Conversely, S. mansoni infection intensity categories lacked association with prevalence of the morbidity measures assessed. Conclusions/significance Current status infection intensity categories for S. haematobium were associated with morbidity levels in school-age children, suggesting urogenital schistosomiasis morbidity can be predicted by an individual’s intensity category. Conversely, S. mansoni infection intensity categories were not consistently indicative of childhood morbidity at baseline or during the first two years of a preventive chemotherapy control program.
Author summary Infections with Schistosoma parasites are commonly classified by the presence and concentration of excreted Schistosoma eggs. Guidelines put forward by the World Health Organization (WHO) include classifications of S. haematobium infections assessed by urine filtration into light and heavy infections and S. mansoni infections assessed by Kato-Katz thick smears into light, moderate, and heavy infections. Past evidence has demonstrated an association between intensity of infection with morbidity for severe morbidities, but this was before recognition of the effect of light-intensity infections on morbidity and was done in treatment naïve populations. In these analyses, we assessed the associations between the WHO classifications for infection intensity and a wide array of S. haematobium and S. mansoni morbidity indicators in school-age children ascertained in monitoring and evaluation cohorts before and after initiation of deworming. Our analyses found a high correlation with S. haematobium intensity categories and morbidity indicators, especially microhematuria, but weaker correlation between S. mansoni intensity categories and morbidity indicators. The results indicate that, on the aggregate, the intensity categories represent a person’s S. haematobium-related morbidity but are poor at representing a person’s S. mansoni-related morbidity.
Databáze: OpenAIRE
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