Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine
| Autor: | Zhendong Zhu, Helen Shi, Gwen Fate, Linning Yu, Billie J. Kline, Michael P. Pollastri, Wing Lam, Kathleen A. Farley, Francoise Berlioz, Cyrille Kuhn, Jeannine Delaney, Gregory S. Walker, Marc Bazin |
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| Rok vydání: | 2007 |
| Předmět: |
Iodosobenzene
Metalloporphyrins Iron Inorganic chemistry Biochemistry Chloride Medicinal chemistry Catalysis chemistry.chemical_compound Chlorides Drug Discovery medicine Imidazole Reactivity (chemistry) Hydrogen peroxide Aminopyrine Pharmacology Molecular Structure Organic Chemistry Hydrogen Peroxide Oxidants Solvent chemistry Cumene hydroperoxide Molecular Medicine Oxidation-Reduction medicine.drug |
| Zdroj: | Chemical biologydrug design. 70(4) |
| ISSN: | 1747-0277 |
| Popis: | Major metabolites of dimethylaminoantipyrine have been synthesized using iron ortho-nitrophenylporphyrin chloride as biomimetic catalyst. Reactivity of iron tetrakis-ortho-nitrophenylporphyrin chloride [Fe(TNO2PP)Cl] has been compared with iron tetrakis-pentafluorophenylporphyrin chloride and iron tetrakis-2,6-dichlorophenylporphyrin chloride using various oxidants such as hydrogen peroxide, iodosobenzene, and cumene hydroperoxide in either protic or aprotic solvent. Effect of imidazole has been showed on the reactivity of Fe(TNO2PP)Cl/cumene hydroperoxide system. |
| Databáze: | OpenAIRE |
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