Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5 years of life

Autor: Keith J. Chappell, Patrick G. Holt, Stephen B. Lambert, Merci M.H. Kusel, Daniel Watterson, Paul R. Young, Keith Grimwood, Barbara J. Holt, Mari Takashima, Robert S. Ware, Peter D. Sly
Rok vydání: 2021
Předmět:
Zdroj: Pediatric Pulmonology. 56:3942-3951
ISSN: 1099-0496
8755-6863
Popis: OBJECTIVE: To determine the potential longer-term effects of maternal antenatal respiratory syncytial virus (RSV) vaccination, we examined the association between cord-blood RSV-neutralizing antibodies (RSV-NA) and RSV infections in the first 2-years of life, RSV-NA at 3-years, and respiratory health to age 5-years. METHODS: Two community-based Australian birth cohorts were combined. For children with at least one atopic parent, paired serum RSV-NA levels were compared in cord-blood and at age 3-years. Weekly nasal swabs were collected in one cohort and during acute respiratory infections (ARI) in the other. Wheeze history up to age 5-years and physician-diagnosed asthma at 5-years was collected by parent report. RESULTS: In 264 children, each log10 increase of cord-blood RSV-NA level was associated with 37% decreased risk (adjusted incidence-rate-ratio (aIRR) 0.63; 95% confidence interval (CI): 0.40-1.01) of RSV-ARI and 49% decreased risk (aIRR 0.51; 95%CI: 0.25-1.02) of RSV acute lower respiratory infections (ALRI) at 12-24 months of age. However, higher cord-blood RSV-NA was associated with increased risk of all-cause ALRI (aIRR 1.29; 95%CI: 0.99-1.69), wheeze-associated ALRI (aIRR 1.75; 95%CI: 1.08-2.82) and severe ALRI (aIRR 2.76; 95%CI: 1.63-4.70) at age 6
Databáze: OpenAIRE
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