Gender, metabolic control and carotid intima-media-thickness in children and adolescents with type 1 diabetes mellitus
| Autor: | Maria Fritsch, Edith Schober, Michael E. Gschwandtner, Andrea Willfort-Ehringer, Oliver Schlager, Birgit Rami-Merhar, Renate Koppensteiner, Georgiana-Aura Giurgea, Sabine Steiner, Clemens Höbaus, Thomas Hörtenhuber, Gerit-Holger Schernthaner, Katrin Nagl, Christian Margeta |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Adolescent Comorbidity Carotid Intima-Media Thickness Sensitivity and Specificity Age Distribution Risk Factors Internal medicine medicine.artery medicine Humans cardiovascular diseases Common carotid artery Sex Distribution Glycemic Type 1 diabetes business.industry Incidence Reproducibility of Results General Medicine medicine.disease Atherosclerosis Causality Endocrinology Blood pressure Diabetes Mellitus Type 1 Treatment Outcome Intima-media thickness Metabolic control analysis Austria Cohort cardiovascular system business Body mass index |
| Zdroj: | Wiener klinische Wochenschrift. 127(3-4) |
| ISSN: | 1613-7671 |
| Popis: | Despite a marked improvement in the overall prognosis of patients with type 1 diabetes mellitus (T1DM), cardiovascular morbidity/mortality is still increased. Since cellular and microvascular aberrations have been demonstrated already in children with T1DM, albeit a good glycemic control (CO), we hypothesized that early macrovascular changes can be detected by common carotid artery intima-media thickness (CCA-IMT). We included 73 children/adolescents with T1DM (34 boys, 39 girls; mean age, 14.8 ± 2 years) and 243 sex- and age-matched healthy CO. In T1DM mean HbA1c was 7.9 ± 1.1 rel.%, and duration of disease 7.5 ± 3.1 years. High-resolution ultrasonography was used to assess CCA-IMT, defined as the mean of 24 measurements of the near and far wall on both right and left CCA. CCA-IMT was not different in the total of children and adolescents with T1DM compared with CO (0.302 ± 0.057 vs. 0.301 ± 0.054 mm; p = 0.88). Analysis according to gender, however, revealed higher CCA-IMT values in girls than in boys in the diabetic cohort (0.315 ± 0.055 vs. 0.288 ± 0.058 mm; p = 0.047), whereas CCA-IMT was higher in boys than in girls in the CO group (0.321 ± 0.057 vs. 0.284 ± 0.045 mm; p |
| Databáze: | OpenAIRE |
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