Urinary Copper Excretion in Type 2 Diabetic Patients with Nephropathy
| Autor: | Takuma Narita, Yoshihiko Kawarada, Seiki Ito, Toshiko Yaginuma, Toshihiro Sugiyama, Masami Kawagoe, Hiroki Fujita |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urinary system Urine Nephropathy Diabetic nephropathy Excretion Internal medicine medicine Albuminuria Humans Diabetic Nephropathies Aged biology business.industry Albumin Ceruloplasmin Hydrogen-Ion Concentration Middle Aged medicine.disease Kidney Tubules Endocrinology Diabetes Mellitus Type 2 Creatinine biology.protein Female medicine.symptom business Copper |
| Zdroj: | Nephron. 88:307-312 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | Background/Aims: The aim of this study was to examine the relationship between the degree of urinary copper excretion and stages of diabetic nephropathy. Methods: Copper, ceruloplasmin and albumin concentrations were measured in serum and urine samples from 41 type 2 diabetic outpatients with different stages of nephropathy and from 10 healthy controls. The copper/albumin and copper/ceruloplasmin ratios in serum and urine were determined. Furthermore, we examined whether free copper ions are dissociated from ceruloplasmin under various pH conditions. Results: Urinary copper concentrations significantly increased only in macroalbuminuric patients. The copper/ceruloplasmin and copper/albumin ratios in urine were consistently greater than those in serum which were not different between patients and healthy controls except the copper/albumin ratio in macroalbuminuric patients. The ratios in urine decreased in parallel with the progression of nephropathy. Copper was found to be released from ceruloplasmin under acidic conditions. Conclusion: Urinary copper excretion in healthy controls may be the result of dissociation from the albumin-copper complex of serum during its passage through the kidney. In diabetic patients with advanced nephropathy, urinary copper excretion may be due to dissociations from both copper-albumin and ceruloplasmin-copper complexes filtered through the damaged glomerulus. Overloading of urinary copper to damaged renal tubules may play some roles in the progression of nephropathy in patients with advanced nephropathy. |
| Databáze: | OpenAIRE |
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