Effects of co-administration of the GABAB receptor agonist baclofen and a positive allosteric modulator of the GABAB receptor, CGP7930, on the development and expression of amphetamineinduced locomotor sensitization in rats
| Autor: | Laura N. Cedillo, Florencio Miranda |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Agonist Baclofen Allosteric modulator medicine.drug_class Motor Activity Pharmacology Nucleus accumbens GABAB receptor chemistry.chemical_compound Phenols medicine Animals Drug Interactions Rats Wistar Receptor Amphetamine Sensitization Behavior Animal Dose-Response Relationship Drug musculoskeletal neural and ocular physiology Brain General Medicine Rats medicine.anatomical_structure Receptors GABA-B nervous system chemistry GABA-B Receptor Agonists Anesthesia Central Nervous System Stimulants medicine.drug |
| Zdroj: | Pharmacological Reports. 65:1132-1143 |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/s1734-1140(13)71471-3 |
| Popis: | Background Several of the behavioral effects of amphetamine (AMPH) are mediated by an increase in dopamine neurotransmission in the nucleus accumbens. However, evidence shows that γ-aminobutyric acid B (GABA B ) receptors are involved in the behavioral effects of psychostimulants, including AMPH. Here, we examined the effects of co-administration of the GABA B receptor agonist baclofen and a positive allosteric modulator of theGABA B receptor, CGP7930, on AMPH-induced locomotor sensitization. Methods In a series of experiments, we examined whether baclofen (2.0, 3.0 and 4.0 mg/kg), CGP7930 (5.0, 10.0 and 20.0 mg/kg), or co-administration of CGP7930 (5.0, 10.0 and 20.0 mg/kg) with a lower dose of baclofen (2.0 mg/kg) could prevent the development and expression of locomotor sensitization produced by AMPH (1.0 mg/kg). Results The results showed that baclofen treatment prevented both the development and expression of AMPH-induced locomotor sensitization in a dose-dependent manner. Furthermore, the positive allosteric modulator of the GABA B receptor, CGP7930, increased the effects of a lower dose of baclofen on AMPH-induced locomotor sensitization under both conditions. Conclusion These data provide further evidence thatGABA B receptor ligands may modulate psychostimulant-induced behaviors. |
| Databáze: | OpenAIRE |
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