Promising outcome measures of early Alzheimer's dementia in adults with Down syndrome
| Autor: | Nicole Schupf, Wayne Silverman, Joseph H. Lee, Cynthia Kovacs, Deborah Pang, Sharon J. Krinsky-McHale, Tracy Listwan, Warren B. Zigman |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Down syndrome
Psychometrics Disease lcsh:Geriatrics Article lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine mild cognitive impairment medicine Dementia Alzheimer s dementia lcsh:Neurology. Diseases of the nervous system Diagnostic Assessment & Prognosis 030304 developmental biology 0303 health sciences business.industry aging Outcome measures Neuropsychology Alzheimer's disease medicine.disease Clinical trial Psychiatry and Mental health lcsh:RC952-954.6 Neurology (clinical) business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| ISSN: | 2352-8729 |
| Popis: | Introduction Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible. Methods Using a broad battery of neuropsychological assessments, informant interviews, and clinical record review, we evaluated the psychometrics of measures in a large sample of 561 adults with DS. We tracked longitudinal stability or decline in functioning in a subsample of 269 participants over a period of 3 years, all initially without indications of clinically significant aging‐related decline. Results Results identified an array of objective measures that demonstrated sensitivity in distinguishing individuals with incident “mild cognitive impairment” (MCI‐DS) as well as subsequent declines occurring with incident dementia. Discussion Several instruments showed clear promise for use as outcome measures for future clinical trials and for informing diagnosis of individuals suspected of experiencing early signs and symptoms of a progressive dementia process. |
| Databáze: | OpenAIRE |
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