Bone Quality as Measured by Trabecular Bone Score in Normocalcemic Primary Hyperparathyroidism
| Autor: | Andrea Palermo, John P. Bilezikian, Nicola Napoli, Roberto Cesareo, Claudio Pedone, Anda Mihaela Naciu, Daria Maggi, Silvia Manfrini, Diana Lelli, Gaia Tabacco, Stefania Falcone, Giosuè Giordano Incognito, Iacopo Chiodini |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Urology 030209 endocrinology & metabolism 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Endocrinology Trabecular bone score Bone Density Bone quality Humans Medicine 030212 general & internal medicine Dual-energy X-ray absorptiometry Femoral neck Hyperparathyroidism Lumbar Vertebrae medicine.diagnostic_test business.industry Area under the curve General Medicine Hyperparathyroidism Primary medicine.disease Cross-Sectional Studies medicine.anatomical_structure Cancellous Bone business Body mass index Primary hyperparathyroidism |
| Zdroj: | Endocrine Practice. 27:992-997 |
| ISSN: | 1530-891X |
| DOI: | 10.1016/j.eprac.2021.04.884 |
| Popis: | OBJECTIVE The impact of normocalcemic hyperparathyroidism (NHPT) on bone quality remains largely unexplored. We aimed to investigate the usefulness of trabecular bone score (TBS) assessment in NHPT and the accuracy of TBS in predicting vertebral fractures (VFs) in NHPT. METHODS In this multicentric cross-sectional study, we assessed the TBS in 47 subjects with NHPT, 41 with primary hyperparathyroidism (PHPT), and 39 age- and sex-matched control subjects. RESULTS TBS values did not differ among the 3 groups. The prevalence of low TBS (TBS < 1.2) was 23.4% in NHPT, 26.8% in PHPT, and 15.4% in controls, without statistically significant differences between groups. However, we found a lower lumbar spine Z-score adjusted for TBS (LS Z-score∗TBS) in PHPT participants when compared with controls (-0.48 ± 1.06 vs 0.07 ± 0.93, P = .017). In NHPT group, LS Z-score∗TBS did not detect patients with overall VFs (threshold, -0.15; area under the curve, 0.45; 95% CI, 0.253-0.648; accuracy, 55.3%). Instead, it was useful for moderate-severe VFs (threshold, 0.55; area under the curve, 0.81; 95% CI, 0.62-0.996; accuracy, 83%). In PHPT subjects also, TBS did not predict VFs. CONCLUSION In NHPT, TBS is not reduced. When adjusted for TBS, the LS Z-score might predict moderate-to-severe VFs. |
| Databáze: | OpenAIRE |
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