Port-wine Nevus-like Arteriovenous Malformation in a Rhesus Monkey (Macaca mulatta)
| Autor: | M. Ngampochjana, J. R. Latendresse, G. S. Ward |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms H&E stain Arteriovenous Malformations Lesion Venous Hemangioma Dermis medicine Animals Nevus General Veterinary business.industry Monkey Diseases Nodule (medicine) Papule Arteriovenous malformation Anatomy medicine.disease Macaca mulatta medicine.anatomical_structure Macaca Female medicine.symptom Hemangioma business |
| Zdroj: | Veterinary Pathology. 24:197-199 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098588702400219 |
| Popis: | A nevus is a circumscribed developmental defect of the skin that may or may not be congenital and can form from any of one or more integumentary constituents.’ Port-wine nevus is a red-to-purple blemish resulting from telangiectatic capillaries in the and is usually a macule or patch, but can become raised with age. It most often occurs on the face, sometimes covering large areas, and is present at birth. Nevoid arteriovenous (A-V) angiopathy, a distinct human clinical entity, is also found on the face and other locations. Variants of this lesion have been referred to as acral arteriovenous tumor,3 venous hemangioma or phlebangi~ma,~.~.~ and A-V shunt.4 It is usually an acquired, red-to-purple papule or nodule, 1 to 30 mm in diameter, consisting of endothelial-lined, thick-walled and thin-walled fibromuscular vascular channels located in the superficial and middle dermis. Although the classification and histiogenesis of this tumor is controversial, many authors believe that it is a dysplasia and not a true angi~ma.~,~,~ Spontaneous cases of these skin conditions have not been reported in monkeys. We describe a vascular nevus in the rhesus, Macaca mulatta, with a combination of clinicopathologic features of port-wine nevus and nevoid A-V angiopathy that occur in man. The female rhesus (tattoo A2 1) was received from the Naval Aerospace Medical Research Laboratory (Pensacola, FL) in 1984. Present at birth, the blemish was described as “a strawberry-colored birthmark.” After clinical evaluation and quarantine, the monkey was admitted to our breeding colony when she was 4 years old. There has been no change in the clinical appearance of the blemish after nearly 2 years in our laboratory. The monkey has no history of trauma, illness, or being used for experimentation. Three, approximately 0.5 x 1.5 cm pieces of skin were surgically excised from different regions of the blemish, fixed in 10% buffered formalin, and paraffin-embedded. Sections were cut at 5-7 pm and stained with hematoxylin and eosin (HE), Masson’s trichrome, Movat’s pentachrome, and reticulin stains. Macroscopically, the reddish-purple blemishes were unilateral on the left-side of the face, ear, chin, and neck. They were nonelevated and well-circumscribed, but had irregular borders. Small macules were separated by normal-colored skin or coalesced with anastamosing areas to form patches with an ink-blot-like pattern (Fig. 1). Histologically the biopsied skin from three different regions of the blemish had the same morphology. Margins were circumscribed, but did not compress or infiltrate adjacent normal tissue. The lesion was composed of numerous uniformly distributed sections of thick- and thin-walled blood vessels located in the papillary and outer reticular regions of the dermis. Blood vessels were separated by dense collagen |
| Databáze: | OpenAIRE |
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