Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
| Autor: | Christa Meisinger, Bernhard Kuch, Jakob Linseisen, Annette Peters, Timo Schmitz, Christian Thilo, Margit Heier |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Science Myocardial Infarction Calcium and vitamin D Cardiology chemistry.chemical_element 030204 cardiovascular system & hematology Calcium Disease-Free Survival Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Myocardial infarction ddc:610 Registries Aged Multidisciplinary business.industry Proportional hazards model Middle Aged medicine.disease Survival Rate chemistry Quartile Censoring (clinical trials) Medicine Low serum calcium Long term mortality Female business Population-Based Registry 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Sci. Rep. 11:2476 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Calcium plays an essential role in physiology of the cardiovascular system. Aberrations from normal serum calcium levels are known to be associated with several cardiovascular diseases. Its possible role as a predictor for long-term mortality after acute myocardial infarction (AMI) is still uncertain. In this study, a total of 3732 patients (aged 25–74 years) with incident AMI surviving at least 28 days after AMI was included. The median follow-up time was 6.0 years. Admission total serum calcium levels were divided into quartiles. The Kaplan–Meier-Curve suggested a division of the follow up time in two different time periods. So, Cox regression models were calculated to assess association between admission serum calcium levels and all-cause long-term mortality with two observation periods: 28–2500 days and > 2500 days. The final model was adjusted for various comorbidities, clinical characteristics, in-hospital treatment and medication. The third quartile (normal-high Calcium levels) served as the reference group. The fully adjusted Cox-regression model shows significantly higher mortality risk for low serum calcium (quartile 1) within the timeframe 28–2500 days after the event (OR 1.53 [1.19–1.98]). The other groups did not differ significantly from each other. In the later observation period (from 2500 days until death or censoring) no more significant differences were seen between the four calcium quartiles. In summary, low serum calcium is an independent predictor of adverse outcome in the first 2500 days (about 7 years) after AMI. On later points in time this effect attenuates, so that no more significant differences can be observed. |
| Databáze: | OpenAIRE |
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