Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats
| Autor: | Seng-Wong Huang, Wei-Ju Huang, Kok-Min Seow, Ming-Luen Doong, Full-Young Chang, Low-Tone Ho, Jiann-Loung Hwang, Chi Chang Juan, Jyun-Lin Lee |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
endocrine system
medicine.medical_specialty Ovariectomy Endocrinology Diabetes and Metabolism Chorionic Gonadotropin Human chorionic gonadotropin Rats Sprague-Dawley Hormone Antagonists Endocrinology Internal medicine medicine Animals Gastrointestinal Transit Receptor Cholecystokinin Gastric emptying business.industry digestive oral and skin physiology Antagonist Rats Proglumide Gastric Emptying Lorglumide Vomiting Ovariectomized rat Female medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Endocrinology. 216:307-314 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1530/joe-12-0421 |
| Popis: | Prolongation of gastrointestinal transit resulting in nausea and vomiting in pregnancy (NVP) is the most common phenomenon during the first trimester of pregnancy. Increased human chorionic gonadotropin (hCG) concentration during the first trimester is the most likely cause of NVP. The aim of this study was to investigate the effect of hCG on gastrointestinal transit and plasma concentrations of cholecystokinin (CCK) in ovariectomized (Ovx) rats. I.p. injection of hCG was used to evaluate the dose effect of hCG on gastrointestinal transit in Ovx rats. The CCK antagonist lorglumide was used to clarify the role of CCK in regulating gastrointestinal transit. Gastrointestinal transit was assessed 15 min after intragastric gavage of a mixture of 10% charcoal and Na251CrO4(0.5 μCi/ml). After i.p. administration of hCG, gastric emptying was inhibited in Ovx rats, but intestinal transit was not affected. Plasma CCK concentrations were increased in a dose-dependent manner after hCG treatment, and gastric emptying showed a significant negative correlation with CCK concentrations (P=0.01,r2=−0.5104). Peripheral administration (i.p.) of lorglumide, a selective CCK1receptor antagonist, attenuated the hCG-induced inhibition of gastric emptying in Ovx rats, whereas central administration via the i.c.v. route did not. hCG treatment of Ovx rats inhibits gastric emptying in a dose-dependent manner via a peripheral mechanism of CCK hypersecretion and activation of CCK1receptors. |
| Databáze: | OpenAIRE |
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