Translational potential of human brain organoids

Autor:	Alfred Xuyang Sun, Huck-Hui Ng, Eng-King Tan
Rok vydání:	2018
Předmět:	0301 basic medicine business.industry General Neuroscience Human brain 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Organoid Medicine Neurology (clinical) Stem cell business Point of View Neuroscience
Zdroj:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
Popis:	The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several physiological and pathological functions of the brain. Here we provide an overview of the development of brain organoids for the clinical community, focusing on the current status of the field with an critical evaluation of its translational value.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce206fa772083b9edbd74f8f2690096c https://doi.org/10.1002/acn3.505 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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